年轻时接受放射治疗与继发性甲状腺癌有关。晚期效应研究小组。

Therapeutic radiation at a young age is linked to secondary thyroid cancer. The Late Effects Study Group.

作者信息

Tucker M A, Jones P H, Boice J D, Robison L L, Stone B J, Stovall M, Jenkin R D, Lubin J H, Baum E S, Siegel S E

机构信息

Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 20892.

出版信息

Cancer Res. 1991 Jun 1;51(11):2885-8.

PMID:1851664

Abstract

We estimated the risk of thyroid cancer among 9170 patients who had survived 2 or more years after the diagnosis of a cancer in childhood. As compared with the general population, patients had a 53-fold increased risk (95% confidence interval, 34-80). Risk increased significantly with time since treatment for the initial cancer (P = 0.03). Detailed treatment data were obtained for 23 cases and 89 matched controls from the childhood cancer cohort. Sixty-eight % of the thyroid cancers arose within the field of radiation. Radiation doses to the thyroid of greater than 200 cGy were associated with a 13-fold increased risk (95% confidence interval, 1.7-104). The risk of thyroid cancer rose with increasing dose (P less than 0.001), but this was derived almost entirely from the increase from less than 200 to greater than 200 cGy. The risk of thyroid cancer did not decrease, however, at radiation doses as high as 6000 cGy.

摘要

我们对9170例童年期癌症诊断后存活2年或更长时间的患者的甲状腺癌风险进行了评估。与普通人群相比，这些患者患甲状腺癌的风险增加了53倍（95%置信区间为34 - 80）。自最初癌症治疗后的风险随时间显著增加（P = 0.03）。从儿童癌症队列中获取了23例病例和89例匹配对照的详细治疗数据。68%的甲状腺癌发生在放疗区域内。甲状腺接受大于200 cGy的辐射剂量与风险增加13倍相关（95%置信区间为1.7 - 104）。甲状腺癌风险随剂量增加而上升（P小于0.001），但这几乎完全源于剂量从小于200 cGy增加到大于200 cGy。然而，即使辐射剂量高达6000 cGy，甲状腺癌风险也没有降低。