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病毒糖蛋白与胰蛋白酶的结合及其与毒力的关系。II. 牛胰蛋白酶和灰色链霉菌胰蛋白酶的比较。

Binding of viral glycoprotein with trypsin and its relation to virulency. II. Comparison between bovine and Streptomyces griseus trypsins.

作者信息

Miyata K, Kiho Y, Hosaka Y

机构信息

Central Research Institute, Ishihara Sangyo Kaisha Ltd., Shiga, Japan.

出版信息

Cell Struct Funct. 1991 Feb;16(1):39-43. doi: 10.1247/csf.16.39.

DOI:10.1247/csf.16.39
PMID:1851673
Abstract

The two step nature of the binding reaction between trypsin and viral glycoproteins was further investigated using two types of trypsin, bovine trypsin and Streptomyces griseus trypsin. The experimental results were explained by the van der Waals energy operating in the second step, suggesting that the conformational aspects, in addition to the electrostatic nature, of the interacting peptides are decisive in this specific process.

摘要

使用两种类型的胰蛋白酶,即牛胰蛋白酶和灰色链霉菌胰蛋白酶,进一步研究了胰蛋白酶与病毒糖蛋白之间结合反应的两步性质。实验结果由第二步中起作用的范德华能量来解释,这表明除了静电性质外,相互作用肽的构象方面在这个特定过程中起决定性作用。

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