Lagache Thibault, Holcman David
Department of Biology, Ecole Normale Supérieure, 46 rue d'Ulm 75005 Paris, France.
Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Mar;77(3 Pt 1):030901. doi: 10.1103/PhysRevE.77.030901. Epub 2008 Mar 24.
Active cellular transport is a fundamental mechanism for protein and vesicle delivery, cell cycle, and molecular degradation. Viruses can hijack the transport system and use it to reach the nucleus. Most transport processes consist of intermittent dynamics, where the motion of a particle, such as a virus, alternates between pure Brownian and directed movement along microtubules. In this Rapid Communication, we estimate the mean time for a particle to attach to a microtubule network. This computation leads to a coarse grained equation of the intermittent motion in radial and cylindrical geometries. Finally, by using the degradation activity inside the cytoplasm, we obtain refined asymptotic estimations for the probability and the mean time a virus reaches a small nuclear pore.
主动细胞运输是蛋白质和囊泡递送、细胞周期及分子降解的基本机制。病毒可劫持运输系统并利用它抵达细胞核。大多数运输过程由间歇性动力学组成，其中诸如病毒等粒子的运动在纯粹的布朗运动和沿微管的定向运动之间交替。在这篇快速通讯中，我们估算了一个粒子附着到微管网络的平均时间。该计算得出了径向和柱面几何结构中间歇性运动的粗粒度方程。最后，通过利用细胞质内的降解活性，我们获得了关于病毒到达小核孔的概率和平均时间的精细渐近估计。
