Halper J P, Miller A H, Trestman R L, Santucci A C, Lackner C, Stein M
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029.
J Neuroimmunol. 1991 Jun;32(3):241-7. doi: 10.1016/0165-5728(91)90194-c.
Splenic mononuclear cells isolated from rats exposed to two brief stressors (5 min of restraint or 2 min of footshock) showed a diminished response to the T cell mitogens, concanavalin A and phytohemagglutinin. Cells from these stressed animals also exhibited a diminished response to stimulation with the phorbol ester, tetradecanoylphorbol acetate (TPA), and/or the calcium ionophore, ionomycin. Since stimulation with these latter two agents mimics early signals generated by mitogen surface receptor binding including increased intracellular calcium and protein kinase C activation, the data indicate that stress-related defects in T cell proliferation occur at sites other than or in addition to these early events in cellular activation.
从经历两种短暂应激源（5分钟束缚或2分钟足底电击）的大鼠中分离出的脾单核细胞，对T细胞有丝分裂原刀豆球蛋白A和植物血凝素的反应减弱。来自这些应激动物的细胞对佛波酯十四酰佛波醇乙酸酯（TPA）和/或钙离子载体离子霉素的刺激反应也减弱。由于用后两种试剂刺激模拟了由有丝分裂原表面受体结合产生的早期信号，包括细胞内钙增加和蛋白激酶C激活，数据表明T细胞增殖中与应激相关的缺陷发生在细胞活化的这些早期事件之外或之外的部位。
