Sethi Nitin K, Harden Cynthia L
Comprehensive Epilepsy Center, Weill Cornell Medical College, New York, NY 10021, USA.
Menopause Int. 2008 Jun;14(2):85-7. doi: 10.1258/mi.2008.008001.
Women suffering from epilepsy require special attention throughout their life. In this review, management of epilepsy during the periods of perimenopause, menopause and late maturity is discussed. The effect of epilepsy on age at menopause, changes in seizure frequency during perimenopause and menopause, and the risks of hormone replacement therapy are also presented. Altered antiepileptic drug pharmacokinetics with increasing age and the management of this vulnerable population is also discussed.
患有癫痫的女性在其一生中都需要特别关注。在这篇综述中,讨论了围绝经期、绝经和高龄期癫痫的管理。还介绍了癫痫对绝经年龄的影响、围绝经期和绝经期间癫痫发作频率的变化以及激素替代疗法的风险。同时也讨论了随着年龄增长抗癫痫药物药代动力学的改变以及对这一脆弱人群的管理。