Safronova V G, Chemeris N K
Neirofiziologiia. 1991;23(1):43-8.
Voltage-activated calcium current was recorded in isolated neurons of Lymnaea stagnalis under voltage clamp and intracellular dialysis conditions. Calcium current was modulated by non-hydrolyzable guanine nucleotide analogue, guanosine-5'-0-3-thiotriphosphate (GTP gamma S), in a receptor-mediated manner: effect of 100 microM GTP gamma S was recorded at activation of the dopamine receptor. The results obtained permitted suggesting that the effect of dopamine on calcium channels in these neurons is a GTP-dependent one.
在电压钳制和细胞内透析条件下,记录了椎实螺分离神经元中的电压激活钙电流。钙电流由不可水解的鸟嘌呤核苷酸类似物鸟苷-5'-O-3-硫代三磷酸(GTPγS)以受体介导的方式进行调节:在多巴胺受体激活时记录了100μM GTPγS的作用。所获得的结果表明,多巴胺对这些神经元中钙通道的作用是依赖于GTP的。