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[不可水解的鸟苷三磷酸类似物对蜗牛神经元中钙电流多巴胺调节的影响]

[Effect of the non-hydrolyzable guanosine triphosphate analogue on dopamine modulation of the calcium current in a snail neuron].

作者信息

Safronova V G, Chemeris N K

出版信息

Neirofiziologiia. 1991;23(1):43-8.

PMID:1851968
Abstract

Voltage-activated calcium current was recorded in isolated neurons of Lymnaea stagnalis under voltage clamp and intracellular dialysis conditions. Calcium current was modulated by non-hydrolyzable guanine nucleotide analogue, guanosine-5'-0-3-thiotriphosphate (GTP gamma S), in a receptor-mediated manner: effect of 100 microM GTP gamma S was recorded at activation of the dopamine receptor. The results obtained permitted suggesting that the effect of dopamine on calcium channels in these neurons is a GTP-dependent one.

摘要

在电压钳制和细胞内透析条件下,记录了椎实螺分离神经元中的电压激活钙电流。钙电流由不可水解的鸟嘌呤核苷酸类似物鸟苷-5'-O-3-硫代三磷酸(GTPγS)以受体介导的方式进行调节:在多巴胺受体激活时记录了100μM GTPγS的作用。所获得的结果表明,多巴胺对这些神经元中钙通道的作用是依赖于GTP的。

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