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检查孕妇牙科治疗的安全性。

Examining the safety of dental treatment in pregnant women.

作者信息

Michalowicz Bryan S, DiAngelis Anthony J, Novak M John, Buchanan William, Papapanou Panos N, Mitchell Dennis A, Curran Alice E, Lupo Virginia R, Ferguson James E, Bofill James, Matseoane Stephen, Deinard Amos S, Rogers Tyson B

机构信息

University of Minnesota School of Dentistry, 17-116 Moos Tower, 515 Delaware St. S.E., Minneapolis, Minn. 55455, USA.

出版信息

J Am Dent Assoc. 2008 Jun;139(6):685-95. doi: 10.14219/jada.archive.2008.0250.

Abstract

BACKGROUND

Although clinicians generally consider it safe to provide dental care for pregnant women, supporting clinical trial evidence is lacking. This study compares safety outcomes from a trial in which pregnant women received scaling and root planing and other dental treatments.

METHODS

The authors randomly assigned 823 women with periodontitis to receive scaling and root planing, either at 13 to 21 weeks' gestation or up to three months after delivery. They evaluated all subjects for essential dental treatment (EDT) needs, defined as the presence of moderate-to-severe caries or fractured or abscessed teeth; 351 women received complete EDT at 13 to 21 weeks' gestation. The authors used Fisher exact test and a propensity-score adjustment to compare rates of serious adverse events, spontaneous abortions/stillbirths, fetal/congenital anomalies and preterm deliveries (<37 weeks' gestation) between groups, according to the provision of periodontal treatment and EDT.

RESULTS

Rates of adverse outcomes did not differ significantly (P> .05) between women who received EDT and those who did not require this treatment, or between groups that received both EDT and periodontal treatment, either EDT or periodontal treatment alone, or no treatment. Use of topical or local anesthetics during root planing also was not associated with an increased risk of experiencing adverse outcomes.

CONCLUSIONS

EDT in pregnant women at 13 to 21 weeks' gestation was not associated with an increased risk of experiencing serious medical adverse events or adverse pregnancy outcomes. Data from larger studies and from groups with other treatment needs are needed to confirm the safety of dental care in pregnant women.

CLINICAL IMPLICATIONS

This study provides evidence that EDT and use of topical and local anesthetics are safe in pregnant women at 13 to 21 weeks' gestation.

摘要

背景

尽管临床医生通常认为为孕妇提供牙科护理是安全的,但缺乏支持这一观点的临床试验证据。本研究比较了一项试验中的安全结果,在该试验中孕妇接受了洗牙和根面平整以及其他牙科治疗。

方法

作者将823名患有牙周炎的女性随机分为两组,一组在妊娠13至21周接受洗牙和根面平整,另一组在分娩后三个月内接受。他们评估了所有受试者的基本牙科治疗(EDT)需求,定义为存在中度至重度龋齿、牙齿折断或脓肿;351名女性在妊娠13至21周接受了完整的EDT。作者使用Fisher精确检验和倾向评分调整,根据牙周治疗和EDT的提供情况,比较两组之间严重不良事件、自然流产/死产、胎儿/先天性异常和早产(妊娠<37周)的发生率。

结果

接受EDT的女性与不需要这种治疗的女性之间,以及接受EDT和牙周治疗、单独接受EDT或牙周治疗或未接受治疗的组之间,不良结局发生率无显著差异(P>.05)。在根面平整过程中使用局部或表面麻醉剂也与不良结局风险增加无关。

结论

妊娠13至21周的孕妇接受EDT与严重医疗不良事件或不良妊娠结局风险增加无关。需要来自更大规模研究和有其他治疗需求人群的数据来证实孕妇牙科护理的安全性。

临床意义

本研究提供了证据,表明妊娠13至21周的孕妇接受EDT以及使用局部和表面麻醉剂是安全的。

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