Kikura-Hanajiri Ruri, Kawamura Maiko, Uchiyama Nahoko, Ogata Jun, Kamakura Hiroyuki, Saisho Kazuhiro, Goda Yukihiro
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, Japan.
Yakugaku Zasshi. 2008 Jun;128(6):971-9. doi: 10.1248/yakushi.128.971.
In the last 10 years, many analogs of narcotic substances have been widely distributed in Japan as easily available psychotropic substances and this has become a serious problem. They have been sold as video cleaners, incense and reagents via the Internet or in video shops. They are not controlled under the Narcotics and Psychotropics Control Law because their pharmacological effects have not yet been proved scientifically. As a countermeasure to prevent the abuse of these substances, the Ministry of Health, Labor and Welfare amended the Pharmaceutical Affairs Law in 2006 so that 31 non-controlled psychotropic substances (11 tryptamines, 11 phenethylamines, 6 alkyl nitrites, 2 piperazines and salvinorin A) and 1 plant (Salvia divinorum) are now controlled as "Designated Substances (Shitei-Yakubutsu)" as of April 2007. Five other compounds (4 phenethylamines and 1 piperazine) were also added to this category in January 2008. In this study, we developed simultaneous analytical methods for these designated substances using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) and present retention times, UV spectra, electron ionization (EI), GC-MS, and electrospray ionization (ESI) LC-MS data.
在过去十年中，许多麻醉药品类似物作为容易获取的精神药物在日本广泛传播，这已成为一个严重问题。它们通过互联网或在音像店作为视频清洁液、香薰和试剂出售。由于其药理作用尚未得到科学证实，它们不受《麻醉药品和精神药物管制法》的管制。作为防止这些物质滥用的一项对策，厚生劳动省于2006年修订了《药事法》，自2007年4月起，31种非管制精神药物（11种色胺、11种苯乙胺、6种亚硝酸烷基酯、2种哌嗪和鼠尾草碱A）和1种植物（迷幻鼠尾草）被作为“指定物质（特定薬物）”进行管制。另外5种化合物（4种苯乙胺和1种哌嗪）也于2008年1月被归入此类。在本研究中，我们开发了使用气相色谱 - 质谱联用仪（GC - MS）和液相色谱 - 质谱联用仪（LC - MS）对这些指定物质进行同时分析的方法，并给出了保留时间、紫外光谱、电子电离（EI）、GC - MS和电喷雾电离（ESI）LC - MS数据。
