我们摄入的过敏原够多吗？
Are we getting enough allergens?
作者信息
Linneberg Allan
机构信息
Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark.
出版信息
Int Arch Allergy Immunol. 2008;147(2):93-100. doi: 10.1159/000135695. Epub 2008 Jun 3.
Abstract
This paper proposes that reduced allergen exposure is one of the factors underlying the higher risk of IgE-mediated allergic disease in populations with an urbanized, westernized, and affluent lifestyle. This lower allergen exposure results in the failure to induce and maintain immune tolerance to common environmental allergens. The paper summarizes different lines of evidence that may support or contradict this hypothesis and points to areas where more knowledge is needed.
摘要
本文提出，在具有城市化、西方化和富裕生活方式的人群中，变应原暴露减少是IgE介导的过敏性疾病风险较高的潜在因素之一。这种变应原暴露的减少导致无法诱导和维持对常见环境变应原的免疫耐受。本文总结了可能支持或反驳这一假设的不同证据，并指出了需要更多知识的领域。
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