Yamamoto Yuka, Nishiyama Yoshihiro, Ishikawa Shinya, Gotoh Masashi, Bandoh Shuji, Kanaji Nobuhiro, Asakura Masato, Ohkawa Motoomi
Department of Radiology, Faculty of Medicine, Kagawa University Hospital, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, Japan.
J Comput Assist Tomogr. 2008 May-Jun;32(3):432-7. doi: 10.1097/RCT.0b013e3180980db9.
The purpose of this study was to evaluate the accuracy of 3'-deoxy-3'-F-fluorothymidine (FLT) positron emission tomography (PET) for detection of lung tumor in comparison with 2-deoxy-2-F-fluoro-D-glucose (FDG) PET.
Fifty-four patients with newly diagnosed pulmonary nodules on chest computed tomographic (CT) scan suggestive of a malignant tumor were examined with both FLT and FDG PET. The intensity of uptake in lung tumors was scored. For visualized lesions, the maximum standardized uptake value (SUV) was calculated.
Thirty-six patients were found to have lung cancer; and 18, benign lesions. Using visual analysis, the sensitivity of FLT PET for detection of lung cancer was 83%; the specificity, 83%; and the accuracy, 83%. The corresponding values for FDG PET were 97%, 50%, and 81%, respectively. The specificity of FLT PET was significantly higher than that of FDG PET. The uptake of FLT in lung cancer was significantly lower than that of FDG. Using semiquantitative analysis, the sensitivity of FLT was 86%; the specificity, 72%; and the accuracy, 81%. The corresponding values for FDG were 89%, 67%, and 81%, respectively.
These preliminary results indicate that FLT PET may be specific for malignant tumors although uptake of FLT in lung cancer was significantly lower than that of FDG.
本研究旨在评估3'-脱氧-3'-氟胸腺嘧啶核苷（FLT）正电子发射断层扫描（PET）与2-脱氧-2-氟-D-葡萄糖（FDG）PET相比，在检测肺肿瘤方面的准确性。
对54例胸部计算机断层扫描（CT）显示新诊断的肺结节且怀疑为恶性肿瘤的患者进行了FLT和FDG PET检查。对肺肿瘤的摄取强度进行评分。对于可视化病变，计算最大标准化摄取值（SUV）。
36例患者被发现患有肺癌；18例为良性病变。采用视觉分析，FLT PET检测肺癌的敏感性为83%；特异性为83%；准确性为83%。FDG PET的相应值分别为97%、50%和81%。FLT PET的特异性显著高于FDG PET。肺癌中FLT的摄取显著低于FDG。采用半定量分析，FLT的敏感性为86%；特异性为72%；准确性为81%。FDG的相应值分别为89%、67%和81%。
这些初步结果表明，尽管肺癌中FLT的摄取显著低于FDG，但FLT PET可能对恶性肿瘤具有特异性。
