Modafferi Antonella M E, Diana Marco, Nicoletti Ferdinando, Scaccianoce Sergio
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy.
Neuroreport. 2008 Jun 11;19(9):911-4. doi: 10.1097/WNR.0b013e3283021cc0.
We examined the effects of chronic morphine treatment and withdrawal on the expression of metabotropic glutamate (mGlu)1, mGlu5, and mGlu2/3 receptors in the nucleus accumbens and caudate putamen. Rats received a 14-day morphine treatment (escalating doses from 10 to 140 mg/kg). Receptor density was evaluated after chronic treatment and after 1, 3, and 14 days of withdrawal. mGlu1 and mGlu5 expression in the nucleus accumbens and in the caudate putamen was not affected by any of the experimental manipulations. In contrast, mGlu2/3 receptors in the nucleus accumbens, but not in the caudate putamen, increased at day 1, 3, and 14 of withdrawal. We suggest that an increased expression of mGlu2/3 receptors in the nucleus accumbens might contribute to the symptoms of morphine withdrawal.
我们研究了慢性吗啡治疗及戒断对伏隔核和尾状壳核中代谢型谷氨酸（mGlu）1、mGlu5和mGlu2/3受体表达的影响。大鼠接受为期14天的吗啡治疗（剂量从10毫克/千克递增至140毫克/千克）。在慢性治疗后以及戒断1天、3天和14天后评估受体密度。伏隔核和尾状壳核中的mGlu1和mGlu5表达不受任何实验操作的影响。相比之下，伏隔核中的mGlu2/3受体在戒断第1天、3天和14天增加，而尾状壳核中的mGlu2/3受体则未增加。我们认为伏隔核中mGlu2/3受体表达增加可能导致吗啡戒断症状。
