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小脑幕脑膜瘤:随访复查

Tentorial meningiomas: follow-up review.

作者信息

Colli Benedicto Oscar, Assirati João Alberto, Deriggi Danilo Jorge Pinho, Neder Luciano, dos Santos Antonio Carlos, Carlotti Carlos Gilberto

机构信息

Division of Neurosurgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

出版信息

Neurosurg Rev. 2008 Oct;31(4):421-30; discussion 430. doi: 10.1007/s10143-008-0141-9. Epub 2008 Jun 3.

Abstract

Tentorial meningiomas comprise 3-5% of the intracranial meningiomas. Different locations and sinus invasion require special surgical skills. This study aimed to analyze factors influencing the outcome of 29 patients (30 tumors) with tentorial meningiomas surgically treated. The study included 22 female and seven male patients, with age of 18-76 years old, and a follow-up of 6-179 months. Eight tumors were located on the inner tentorial ring, 15 on the outer ring, four were falcotentorial, and three attached/invading the torcula. Outcome was analyzed using survival and recurrence-free survival (RFS) curves. Twenty-seven tumors were WHO grade I and three were grades II-III. Total and subtotal resections were reached in 87.5% and 12.5% of tumors. Survival was better for patients with grade I tumors and similar according to sex, location, size, and extent of resection. Recurrence/regrowing rate was 12.5%. RFS curves were better for patients with grade I or with radical resection and similar according to sex, location, and size. There was no operative mortality. Permanent postoperative cranial nerve deficits occurred in 9.7% (all inner ring tumors). Despite being many times large-sized, surgical treatment of tentorial meningiomas gives good results. Prognostic factors for recurrence were histopathologic grade III and subtotal resection. Radical resection allowed better results. Nevertheless, subtotal resection may be acceptable for cases with cranial nerves or sinuses invasions.

摘要

小脑幕脑膜瘤占颅内脑膜瘤的3% - 5%。不同的位置和窦侵犯需要特殊的手术技巧。本研究旨在分析影响29例(30个肿瘤)接受手术治疗的小脑幕脑膜瘤患者预后的因素。该研究包括22例女性和7例男性患者,年龄在18 - 76岁之间,随访时间为6 - 179个月。8个肿瘤位于小脑幕内环,15个位于外环,4个为小脑镰幕型,3个附着于/侵犯窦汇。使用生存曲线和无复发生存(RFS)曲线分析预后。27个肿瘤为世界卫生组织I级,3个为II - III级。87.5%的肿瘤实现了全切除和次全切除,分别占12.5%。I级肿瘤患者的生存率更高,并且根据性别、位置、大小和切除范围,生存率相似。复发/再生长率为12.5%。I级或接受根治性切除的患者的RFS曲线更好,并且根据性别、位置和大小相似。无手术死亡。术后永久性脑神经功能缺损发生率为9.7%(均为内环肿瘤)。尽管小脑幕脑膜瘤大多体积较大,但手术治疗仍能取得良好效果。复发的预后因素是组织病理学III级和次全切除。根治性切除可取得更好的效果。然而,对于伴有脑神经或窦侵犯的病例,次全切除可能是可以接受的。

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