印度南部HIV感染患者口腔中念珠菌属的携带情况。
Carriage of Candida species in oral cavities of HIV infected patients in South India.
作者信息
Girish Kumar C P, Menon Thangam, Rajasekaran S, Sekar B, Prabu D
机构信息
Department of Microbiology, Dr A. L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, India.
出版信息
Mycoses. 2009 Jan;52(1):44-8. doi: 10.1111/j.1439-0507.2008.01534.x. Epub 2008 Jun 3.
Fifty-four patients with human immunodeficiency virus (HIV) infection were studied to assess the load of oral carriage of Candida spp. The mean oral Candida carriage density (30,305.93 +/- 56,643.93 CFU ml(-1)) in HIV patients was significantly higher than that seen in the control population (93.48 +/- 358.48 CFU ml(-1); P = 0.000). The mean Candida load in HIV patients with oral thrush (46,591.43 +/- 65,002.57 CFU ml(-1)) was significantly higher than in the HIV subjects without oral thrush (306.32 +/- 699.50 CFU ml(-1); P = 0.000). Non-C. albicans Candida species (56%) were more predominant than the C. albicans (44%) isolates. 25S rDNA PCR analysis of C. albicans revealed preponderance of genotype A strains. Interestingly, 42.6% of rinse specimens grew multiple Candida species, with the combination of C. albicans and C. krusei (39.1%) being the most frequent.
对54例人类免疫缺陷病毒（HIV）感染者进行了研究，以评估念珠菌属的口腔携带量。HIV患者的口腔念珠菌携带平均密度（30305.93±56643.93 CFU/ml）显著高于对照组人群（93.48±358.48 CFU/ml；P = 0.000）。患有口腔念珠菌病的HIV患者的念珠菌平均载量（46591.43±65002.57 CFU/ml）显著高于未患口腔念珠菌病的HIV受试者（306.32±699.50 CFU/ml；P = 0.000）。非白色念珠菌（56%）比白色念珠菌（44%）分离株更占优势。对白色念珠菌的25S rDNA PCR分析显示基因型A菌株占优势。有趣的是，42.6%的漱口标本培养出多种念珠菌属，白色念珠菌和克鲁斯念珠菌的组合（39.1%）最为常见。
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