Pezzolato Marzia, Varello Katia, Mascarino Daniela, Bozzato Elisa, Vascellari Marta, Bozzetta Elena
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Area Neuroscienze e Genetica, Laboratorio di Immunoistopatologia, Torino, Italy.
J Vet Med Sci. 2008 May;70(5):513-5. doi: 10.1292/jvms.70.513.
A 5 years old female ferret with an abdominal palpable mass confirmed at echo-graphic examination died during an explorative laparotomy. A single lymph-node-like nodule was found adjacent to the intestinal loops. The round mass well circumscribed, solid and white, histologically, at low magnification, appeared encapsulated and built up by a population of atypical spindle cells arranged in interwoven fascicles. The cells had high anisocytosis degree, moderate mitotic activity and prominent nucleoli. A central area of necrosis was present. To characterise the tumour immunohistochemically cytokeratin, vimentin, S-100, melan-A, vWF, desmin, actin and alpha-actin were applied. Neoplastic cells resulted positive to vimentin, actin and alpha-actin. Based on the histological and immunohistological pattern a diagnosis of leiomyosarcoma was made.
