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德国心脏康复的当代趋势:2000年至2005年的患者特征、药物治疗及危险因素管理

Contemporary trends in cardiac rehabilitation in Germany: patient characteristics, drug treatment, and risk-factor management from 2000 to 2005.

作者信息

Bestehorn Kurt, Wegscheider Karl, Völler Heinz

机构信息

Medical Department, MSD Sharp & Dohme GmbH, Haar, Germany.

出版信息

Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):312-8. doi: 10.1097/HJR.0b013e3282f40e14.

Abstract

BACKGROUND

Cardiac rehabilitation (CR) has a pivotal role in the management of patients with coronary heart disease. We aimed to describe temporal trends and centre variances of patient characteristics, drug prescriptions, and risk-factor management of in-patients in inpatient CR in Germany.

METHODS

Data on 117 983 inpatients in CR, obtained from two large-scale registries (Transparency Registry to Objectify Guideline-Oriented Risk-Factor Management and Registry of Guidelines) were pooled resulting in a database of six yearly cross-sectional samples, repeated over centres. For each response variable, a three-level mixed model (patients within years within centres) shifted to the data. Statistical tests were performed on average time trends over groups, average group levels over years, and on parallelism of trends within groups.

RESULTS

Compared with patients in CR in 2000, patients in CR in 2005 were significantly older and had a higher BMI. They, however, also showed improved control over blood pressure, lipids, and glucose at the beginning of rehabilitation; their use of angiotensin-converting enzyme inhibitors and beta-blockers had increased; whereas their use of statin and acetylsalicylic acid remained relatively stable. At discharge, no changes were noted for blood pressure and glucose--at a high target-level attainment of more than 80%. Lipid values, however, tended to improve over time, with an increase in target-level attainment from 45 to 55%. Large centre effects were noted for age, total cholesterol at entry, and exercise capacity at entry and discharge. In general, sex differences were limited.

DISCUSSION

Compared with previous findings, general management of risk factors before initiation of CR, as well as control over lipid, hypertension, and glucose levels at discharge from CR, have improved over time: this is probably due to more intensive drug treatment.

摘要

背景

心脏康复(CR)在冠心病患者的管理中起着关键作用。我们旨在描述德国住院心脏康复患者的特征、药物处方以及危险因素管理的时间趋势和中心差异。

方法

从两个大型登记处(以指南为导向的危险因素管理透明登记处和指南登记处)获取的117983例心脏康复住院患者的数据进行汇总,形成一个包含六个年度横断面样本的数据库,并在各中心重复。对于每个反应变量,采用三级混合模型(中心内各年份的患者)对数据进行分析。对组间平均时间趋势、多年来的平均组水平以及组内趋势的平行性进行了统计检验。

结果

与2000年接受心脏康复的患者相比,2005年接受心脏康复的患者年龄显著更大,体重指数更高。然而,他们在康复开始时对血压、血脂和血糖的控制也有所改善;血管紧张素转换酶抑制剂和β受体阻滞剂的使用增加;而他汀类药物和乙酰水杨酸的使用保持相对稳定。出院时,血压和血糖没有变化——目标达成率高于80%。然而,血脂值随时间推移有改善趋势,目标达成率从45%提高到55%。在年龄、入院时的总胆固醇以及入院和出院时的运动能力方面,各中心存在较大差异。总体而言,性别差异有限。

讨论

与先前的研究结果相比,心脏康复开始前危险因素的总体管理以及心脏康复出院时对血脂、高血压和血糖水平的控制随着时间的推移有所改善:这可能归因于更强化的药物治疗。

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