Elis Avishay, Pereg David, Tirosh Amir, Shochat Tzippora, Tekes-Manova Dorit, Lishner Michael
Department of Medicine, Meir Medical Center, Kfar Saba, Israel.
Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):325-8. doi: 10.1097/HJR.0b013e3282f50ed8.
Family history is one of the main risk factors for cardiovascular disease, especially in the younger population. These individuals, being closely related to young symptomatic patients, are anticipated to have a high rate of risk factors but also to control them aggressively. The aim of the study was to evaluate the association between family history of cardiovascular disease and risk factors that control as well as reduce risk-reducing behavior among young, healthy adults.
Demographic, clinical and lifestyle parameters of career service personnel of the Israeli Defense Forces, who were checked at the staff periodic examination center, were evaluated. Behavioral and clinical parameters of participants, with and without cardiovascular family history, were compared.
The study cohort comprised 41,099 patients (36,236 men and 4863 women). Of those, 3802 men and 628 women with a family history of cardiovascular disease were identified. Male individuals had a higher rate of treatable risk factors like, obesity (P<0.0005), high blood pressure (P<0.0005), high plasma glucose (P<0.0005) and dyslipidemia (P<0.0005) than individuals without a family history. Among the women, the rate of these risk factors was higher than in the control groups but was statistically significant only for obesity, high blood pressure and high glucose levels. Risk-reducing behavior like regular physical activity and nonsmoking status in both the sexes did not differ between the groups.
Members of the young population with a family history of cardiovascular disease is easily identified but remains largely uncontrolled. Special attention and continued education are required to modify their behavioral and medical parameters.
家族病史是心血管疾病的主要危险因素之一，尤其在年轻人群中。这些与年轻症状性患者密切相关的个体，预计有较高的危险因素发生率，但也需要积极控制这些因素。本研究的目的是评估心血管疾病家族史与年轻健康成年人中危险因素控制以及降低风险行为之间的关联。
对在以色列国防军人员定期体检中心接受检查的职业服务人员的人口统计学、临床和生活方式参数进行评估。比较有和没有心血管家族史的参与者的行为和临床参数。
研究队列包括41,099名患者（36,236名男性和4,863名女性）。其中，识别出3,802名有心血管疾病家族史的男性和628名女性。有家族史的男性比没有家族史的男性有更高比例的可治疗危险因素，如肥胖（P<0.0005）、高血压（P<0.0005）、高血糖（P<0.0005）和血脂异常（P<0.0005）。在女性中，这些危险因素的发生率高于对照组，但仅肥胖、高血压和高血糖水平具有统计学意义。两组中，两性的降低风险行为如定期体育活动和非吸烟状况没有差异。
有心血管疾病家族史的年轻人群很容易识别，但在很大程度上仍未得到控制。需要特别关注并持续进行教育，以改变他们的行为和医疗参数。
