选择性胆囊收缩素拮抗剂L-364,718对痛阈和吗啡镇痛作用的影响。
Influence of the selective cholecystokinin antagonist L-364,718 on pain threshold and morphine analgesia.
作者信息
Poggioli R, Vergoni A V, Sandrini M, Barbafiera L, Marrama D, Bertolini A
机构信息
Institute of Pharmacology, University of Modena, Italy.
出版信息
Pharmacology. 1991;42(4):197-201. doi: 10.1159/000138798.
PMID:1852780
Abstract
The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10 micrograms/mouse and was associated with a reduction of brainstem opiate-binding sites.
摘要
向小鼠脑室内注射剂量为0.5、5、10或20微克/小鼠的胆囊收缩素A受体拮抗剂L-364,718，虽然对疼痛阈值（热板法，51摄氏度）没有影响，但却拮抗了吗啡（10毫克/千克腹腔注射）的镇痛活性。10微克/小鼠的剂量可产生此效应，且与脑干阿片样物质结合位点的减少有关。
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