Alkuraya Hisham S, Al-Kharashi Abdullah S, Alharthi Essam, Chaudhry Imtiaz A
King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia.
Int Ophthalmol. 2009 Oct;29(5):411-3. doi: 10.1007/s10792-008-9237-z. Epub 2008 Jun 5.
To report a case of culture-positive endophthalmitis after intravitreal injection of bevacizumab (Avastin) resulting in a devastating visual outcome.
A retrospective case report of a 51-year-old diabetic women who presented with further decrease in her vision, redness, and mild pain in her eye 3 days after intravitreal injection of Avastin for macular edema due to a branch retinal vein occlusion.
Clinical diagnosis of endophthalmitis was made and, after obtaining a vitreous tap, intravitreal antibiotics were administered. Because of worsening of the endophthalmitis, pars plana vitrectomy was undertaken followed by repeat intravitreal antibiotics injection. The patient's ocular condition improved dramatically; however, her visual acuity did not improve. The cultures from vitreous taps revealed Staphylococcus lugdunesis.
Intravitreal injection of Avastin may be associated with a risk of S. lugdunesis-caused endophthalmitis which can have a devastating effect on the final visual outcome.
报告1例玻璃体内注射贝伐单抗（阿瓦斯汀）后发生培养阳性的眼内炎，导致视力严重受损的病例。
对1例51岁糖尿病女性患者进行回顾性病例报告。该患者因视网膜分支静脉阻塞导致黄斑水肿，在玻璃体内注射阿瓦斯汀3天后出现视力进一步下降、眼红和轻度眼痛。
作出眼内炎的临床诊断，在进行玻璃体穿刺后，给予玻璃体内注射抗生素。由于眼内炎恶化，进行了玻璃体切割术，随后再次进行玻璃体内抗生素注射。患者的眼部状况显著改善；然而，其视力并未提高。玻璃体穿刺培养结果显示为路邓葡萄球菌。
玻璃体内注射阿瓦斯汀可能与路邓葡萄球菌引起的眼内炎风险相关，这可能对最终视力结果产生严重影响。
