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[自体骨软骨移植]

[Autologous osteochondral transplants].

作者信息

Schnettler R, Horas U, Meyer C

机构信息

Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Giessen und Marburg, Standort Giessen, Rudolf-Buchheim-Strasse 7, 35385, Giessen.

出版信息

Orthopade. 2008 Aug;37(8):734-42. doi: 10.1007/s00132-008-1263-z.

DOI:10.1007/s00132-008-1263-z
PMID:18528682
Abstract

Osteochondral transplantation is a treatment option for restoring lesions of the cartilage surface and the underlying subchondral bone. For this technique, osteochondral cylinders are taken from less loaded regions of the knee joint and brought into the defect. It is based on press-fit implantation of osteochondral cylinders that are harvested from the mediocranial or laterocranial aspect of the patellofemoral joint with subsequent stable bony integration of the transplant. Indications for osteochondral transplantation must consider clinical, radiological, and magnetic resonance aspects, and concomitant pathologies of the joint should be eliminated. Isolated grade III and IV cartilage lesions in the load-bearing area of the medial or lateral femoral condyle are considered to be ideal indications for osteochondral transplantations. Further indications are retropatellar defects and lesions of the medial aspect of the talus. The technique is established for defects from 1 cm2 to 3 cm2. At this time, osteochondral transplantation is the only surgical method to achieve long-term coverage of the defect with hyaline cartilage. Donor site morbidity at the patellofemoral joint needs to be discussed because, particularly after the harvest of several cylinders, pain syndromes can develop. Therefore, the technique should be limited to two cylinders with a maximum diameter of 12 mm and one further cylinder with a smaller diameter.

摘要

骨软骨移植是一种修复软骨表面及下方软骨下骨损伤的治疗选择。对于该技术,骨软骨柱取自膝关节负荷较小的区域并植入缺损处。它基于从髌股关节中颅侧或后颅侧获取的骨软骨柱的压配式植入,随后移植体实现稳定的骨整合。骨软骨移植的适应证必须综合考虑临床、放射学和磁共振方面的因素,并且应消除关节的伴随病变。股骨内侧髁或外侧髁负重区孤立的Ⅲ级和Ⅳ级软骨损伤被认为是骨软骨移植的理想适应证。其他适应证包括髌后缺损和距骨内侧病变。该技术适用于面积为1平方厘米至3平方厘米的缺损。目前,骨软骨移植是唯一一种能实现缺损长期被透明软骨覆盖的手术方法。髌股关节供区并发症需要进行讨论,因为特别是在获取多个骨软骨柱后,可能会出现疼痛综合征。因此,该技术应限制在两个最大直径为12毫米的骨软骨柱以及另一个直径较小的骨软骨柱。

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1
[Autologous osteochondral transplants].[自体骨软骨移植]
Orthopade. 2008 Aug;37(8):734-42. doi: 10.1007/s00132-008-1263-z.
2
Bone-cartilage transplantation from the ipsilateral knee for chondral lesions of the talus.取自同侧膝关节的骨软骨移植治疗距骨软骨损伤
Arthroscopy. 2005 Feb;21(2):159-66. doi: 10.1016/j.arthro.2004.10.021.
3
Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee.自体骨栓联合自体软骨细胞植入治疗膝关节骨软骨缺损
Am J Sports Med. 2016 May;44(5):1249-59. doi: 10.1177/0363546516631739. Epub 2016 Mar 10.
4
Surgical treatment of osteochondral lesions of the talus by open-field autologous chondrocyte implantation: a 10-year follow-up clinical and magnetic resonance imaging T2-mapping evaluation.开放式自体软骨细胞移植治疗距骨骨软骨病变:10 年随访的临床和磁共振 T2 成像评估。
Am J Sports Med. 2009 Nov;37 Suppl 1:112S-8S. doi: 10.1177/0363546509349928.
5
Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial.自体软骨细胞移植与骨软骨柱移植用于膝关节软骨修复:一项前瞻性对照试验。
J Bone Joint Surg Am. 2003 Feb;85(2):185-92. doi: 10.2106/00004623-200302000-00001.
6
Evaluation of Knee Donor and Elbow Recipient Sites for Osteochondral Autologous Transplantation Surgery in Capitellar Osteochondritis Dissecans.在肱骨小头剥脱性骨软骨炎中用于自体骨软骨移植手术的膝关节供体部位和肘关节受体部位的评估。
Am J Sports Med. 2016 Feb;44(2):511-20. doi: 10.1177/0363546515620184. Epub 2015 Dec 28.
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Hybrid fixation: evaluation of a novel technique in adult osteochondritis dissecans of the knee.混合固定:一种治疗成人膝关节剥脱性骨软骨炎的新方法的评估。
Knee Surg Sports Traumatol Arthrosc. 2011 Apr;19(4):568-71. doi: 10.1007/s00167-010-1259-1. Epub 2010 Sep 18.
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Arthroscopic autogenous osteochondral transplantation for treating knee cartilage defects: a 2- to 5-year follow-up study.关节镜下自体骨软骨移植治疗膝关节软骨缺损:一项2至5年的随访研究。
Arthroscopy. 2004 Sep;20(7):681-90. doi: 10.1016/j.arthro.2004.06.005.
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[Bone-cartilage transfer for osteochondritis dissecans of the humeral capitellum].[肱骨小头剥脱性骨软骨炎的骨软骨移植]
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Clinical and Radiological Regeneration of Large and Deep Osteochondral Defects of the Knee by Bone Augmentation Combined With Matrix-Guided Autologous Chondrocyte Transplantation.通过骨增量联合基质引导自体软骨细胞移植实现膝关节大而深的骨软骨缺损的临床和影像学再生
Am J Sports Med. 2017 Nov;45(13):3069-3080. doi: 10.1177/0363546517717679. Epub 2017 Aug 4.

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Additive manufacturing of patient-specific, biphasic implants with zonal design for regeneration of osteochondral defects-critical evaluation of the work flow from clinical MRI data to implantation.用于骨软骨缺损再生的具有分区设计的患者特异性双相植入物的增材制造——从临床MRI数据到植入的工作流程的关键评估
Mater Today Bio. 2025 May 13;32:101858. doi: 10.1016/j.mtbio.2025.101858. eCollection 2025 Jun.
2
Autologous Transplantation of Press-fit Bone Cylinders in the Treatment of Pelvic Nonunion.压配骨圆柱自体移植治疗骨盆骨不连。
Orthop Surg. 2019 Jun;11(3):516-523. doi: 10.1111/os.12463. Epub 2019 May 3.
3
Cartilage Surgery in Overweight Patients: Clinical and MRI Results after the Autologous Matrix-Induced Chondrogenesis Procedure.

本文引用的文献

1
Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. Surgical technique.肱骨小头剥脱性骨软骨炎的分类、治疗及结果。手术技术。
J Bone Joint Surg Am. 2008 Mar;90 Suppl 2 Pt 1:47-62. doi: 10.2106/JBJS.G.01135.
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Long term results after implantation of tissue engineered cartilage for the treatment of osteochondral lesions in a minipig model.小型猪模型中组织工程软骨植入治疗骨软骨损伤的长期结果。
J Mater Sci Mater Med. 2008 May;19(5):2029-38. doi: 10.1007/s10856-007-3291-3. Epub 2007 Oct 24.
3
A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes.
超重患者的软骨手术:自体基质诱导软骨形成术后的临床和 MRI 结果。
Biomed Res Int. 2018 May 8;2018:6363245. doi: 10.1155/2018/6363245. eCollection 2018.
4
Matrix-induced autologous chondrocyte implantation (MACI) in the knee: clinical outcomes and challenges.膝关节基质诱导自体软骨细胞植入术(MACI):临床结果与挑战
Knee Surg Sports Traumatol Arthrosc. 2015 Dec;23(12):3729-35. doi: 10.1007/s00167-014-3295-8. Epub 2014 Sep 14.
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[Operative joint-preserving therapy of gonarthrosis].[膝关节病的保留关节手术治疗]
Z Rheumatol. 2014 Apr;73(3):251-64. doi: 10.1007/s00393-013-1319-2.
一项关于马赛克自体骨软骨移植与微骨折术治疗年轻运动员膝关节骨软骨损伤的前瞻性随机临床研究。
Arthroscopy. 2005 Sep;21(9):1066-75. doi: 10.1016/j.arthro.2005.06.018.
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Management of big osteochondral defects of the knee using osteochondral allografts with the MEGA-OATS technique.采用MEGA-OATS技术使用异体骨软骨移植治疗膝关节大面积骨软骨缺损。
Knee. 2005 Oct;12(5):389-93. doi: 10.1016/j.knee.2004.12.008.
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Variation of cell and matrix morphologies in articular cartilage among locations in the adult human knee.成年人类膝关节不同部位关节软骨中细胞和基质形态的变化
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[Five-year results following autogenous osteochondral transplantation to the femoral head].[自体骨软骨移植至股骨头后的五年结果]
Orthopade. 2005 Apr;34(4):320, 322-6. doi: 10.1007/s00132-005-0776-y.
7
[Dislocation of artificial cartilage (SaluCartialge)].[人工软骨(SaluCartialge)脱位]
Unfallchirurg. 2005 Feb;108(2):163-6. doi: 10.1007/s00113-004-0798-7.
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Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial.膝关节自体软骨细胞移植与微骨折术的比较:一项随机试验
J Bone Joint Surg Am. 2004 Mar;86(3):455-64. doi: 10.2106/00004623-200403000-00001.
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The etiology of chondromalacia patellae.髌骨软化症的病因。
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Articular cartilage engineering with autologous chondrocyte transplantation. A review of recent developments.自体软骨细胞移植的关节软骨工程。近期进展综述。
J Bone Joint Surg Am. 2003;85-A Suppl 3:109-15. doi: 10.2106/00004623-200300003-00017.