Water-soluble tripeptide Abeta (9-11) forms amyloid-like fibrils and exhibits neurotoxicity.
作者信息
Naskar Jishu, Drew Michael G B, Deb Ishani, Das Sumantra, Banerjee Arindam
机构信息
Chemistry Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India.
出版信息
Org Lett. 2008 Jul 3;10(13):2625-8. doi: 10.1021/ol8007217. Epub 2008 Jun 5.
PMID:18529009
Abstract
A water-soluble, hydrophilic tripeptide GYE, having sequence identity with the N-terminal segment of amyloid peptides Abeta(9-11), upon self-association exhibits amyloid-like fibrils and significant neurotoxicity towards the Neuro2A cell line. However, the tripeptides GFE and GWE, in which the centrally located tyrosine residue has been replaced by phenylalanine or tryptophan, fail to show amyloidogenic behavior and exhibit little or no neurotoxicity.
摘要
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