[Increased blood flow and incorporation of 3H-proline and 45Ca into the bones of female rats after oophorectomy].

In the submitted experiment the authors investigated changes of the local circulation (by assessing retention of 85Sr microparticles) and incorporation of 3H-proline and 45Ca in bone of female rats following oophorectomy (OOX). Four weeks after OOX retention of 85Sr microparticles in % from 1 g tissue rises significantly in the tibia, distal epiphysis of the femur and in vertebrae (insignificantly in the metaphysis and calva); the blood flow in (1 min-1).kg-1 is significantly increased in the tibia and diaphysis of the femur (the differences are less significant as the scatter of values is greater). No differentiation was found in the circulatory response with regard to the content of compact and trabecular tissue in the tested bone or part of a bone. In the examined soft tissues after OOX no detectable changes of the local circulation were found. It appears thus that the local circulatory reaction after OOX is specific only for bony tissue. Twenty-four hour incorporation of 3H-proline and 45Ca into the tibia of female rats is significantly raised after OOX - along with a rise of circulatory values these changes are obviously part of the enhanced metabolic activity of bony tissue after OOX. The specific reaction of the local circulation in bones to oestrogen deficiency is a potentially significant aspect of their action.