Doyle B J, Morris L G, Callanan A, Kelly P, Vorp D A, McGloughlin T M
Centre for Applied Biomedical Engineering Research (CABER), and Materials and Surface Science Institute, University of Limerick, Limerick, Ireland.
J Biomech Eng. 2008 Jun;130(3):034501. doi: 10.1115/1.2907765.
Abdominal aortic aneurysm (AAA) can be defined as a permanent and irreversible dilation of the infrarenal aorta. AAAs are often considered to be an aorta with a diameter 1.5 times the normal infrarenal aorta diameter. This paper describes a technique to manufacture realistic silicone AAA models for use with experimental studies. This paper is concerned with the reconstruction and manufacturing process of patient-specific AAAs. 3D reconstruction from computed tomography scan data allows the AAA to be created. Mould sets are then designed for these AAA models utilizing computer aided designcomputer aided manufacture techniques and combined with the injection-moulding method. Silicone rubber forms the basis of the resulting AAA model. Assessment of wall thickness and overall percentage difference from the final silicone model to that of the computer-generated model was performed. In these realistic AAA models, wall thickness was found to vary by an average of 9.21%. The percentage difference in wall thickness recorded can be attributed to the contraction of the casting wax and the expansion of the silicone during model manufacture. This method may be used in conjunction with wall stress studies using the photoelastic method or in fluid dynamic studies using a laser-Doppler anemometry. In conclusion, these patient-specific rubber AAA models can be used in experimental investigations, but should be assessed for wall thickness variability once manufactured.
腹主动脉瘤(AAA)可定义为肾下腹主动脉的永久性和不可逆扩张。腹主动脉瘤通常被认为是直径为正常肾下腹主动脉直径1.5倍的主动脉。本文描述了一种制造逼真的硅胶腹主动脉瘤模型以供实验研究使用的技术。本文关注的是针对特定患者的腹主动脉瘤的重建和制造过程。通过计算机断层扫描数据进行三维重建可创建腹主动脉瘤。然后利用计算机辅助设计与制造技术并结合注塑成型方法为这些腹主动脉瘤模型设计模具。所得腹主动脉瘤模型以硅橡胶为基础。对壁厚以及最终硅胶模型与计算机生成模型的总体百分比差异进行了评估。在这些逼真的腹主动脉瘤模型中,发现壁厚平均变化9.21%。记录的壁厚百分比差异可归因于模型制造过程中铸蜡的收缩和硅胶的膨胀。该方法可与使用光弹性法的壁应力研究或使用激光多普勒风速仪的流体动力学研究结合使用。总之,这些针对特定患者的橡胶腹主动脉瘤模型可用于实验研究,但制造后应评估壁厚的变异性。