Cho Jung Hyo, Chung Weon Kuu, Kang Weechang, Choi Sun Mi, Cho Chong Kwan, Son Chang Gue
East-West Cancer Center, Dunsan Hospital of Oriental Medical College, Daejeon University, Daejeon, South Korea.
J Altern Complement Med. 2008 Jun;14(5):523-6. doi: 10.1089/acm.2007.0793.
Radiotherapy-induced xerostomia seriously reduces the quality of life (QOL) for patients with head and neck cancer. This study aimed to investigate the effects of manual acupuncture on objective and subjective assessment of symptom changes in patients with cancer who have with radiation-induced xerostomia.
Twelve (12) patients with radiation-induced xerostomia were randomized into 2 groups (real or sham acupuncture). Acupuncture was conducted twice weekly for 6 weeks in a single-blind setting. The effect was evaluated by measuring whole salivary flow rates (stimulated and unstimulated) and questionnaire-based assessment of subjective symptoms pre- and post-treatment (3 and 6 weeks after acupuncture treatment).
Both groups showed a slight increase in whole salivary flow rates, with no significant difference between them. However, real acupuncture markedly increased unstimulated salivary flow rates, and improved the score for dry mouth according to the xerostomia questionnaire, by 2.33 points versus 0.33 in the controls.
Our results showed the significantly meaningful amelioration of the subjective sensation of xerostomia closely associated with QOL in patients with head and neck cancer treated with irradiation.
放疗引起的口干症严重降低了头颈癌患者的生活质量（QOL）。本研究旨在调查手针疗法对患有放射性口干症的癌症患者症状变化的客观和主观评估的影响。
12例放射性口干症患者被随机分为2组（真针灸组或假针灸组）。在单盲环境下，每周进行2次针灸，共6周。通过测量全唾液流速（刺激和未刺激）以及治疗前和治疗后（针灸治疗后3周和6周）基于问卷的主观症状评估来评估效果。
两组的全唾液流速均略有增加，两组之间无显著差异。然而，真针灸显著提高了未刺激唾液流速，并根据口干症问卷使口干评分提高了2.33分，而对照组提高了0.33分。
我们的结果表明，接受放疗的头颈癌患者的口干主观感觉有显著且有意义的改善，这与生活质量密切相关。
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