Tulek Amela, Mulic Aida, Hogset Martine, Utheim Tor Paaske, Sehic Amer
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Nordic Institute of Dental Materials (NIOM), Oslo, Norway.
Int J Dent. 2021 Oct 22;2021:6043488. doi: 10.1155/2021/6043488. eCollection 2021.
Xerostomia is a subjective sensation of dry mouth. It is commonly associated with salivary gland hypofunction. Both changes in the composition of the saliva and a reduction in the quantity secreted may be an objective finding of dry mouth. Although there are no currently available cures for the conditions resulting in dry mouth, there are several treatment options that give hope for patients who suffer from xerostomia. Individuals with some residual salivary gland function, which are contraindicated to pharmacological therapies, would benefit the most from identifying novel, alternative effective methods for stimulating production of saliva. The aim of this study was to give an overview of the latest and most relevant data related to treatment modalities for the management of dry mouth conditions. The present review was prepared by searching the National Library of Medicine database using the relevant medical terms and their combinations. A total of thirty-three studies met the inclusion criteria. Data were extracted by one author and verified by another.
A number of patients showed positive treatment outcomes, and the adverse effects of both electrical stimulation (ES) and acupuncture have been reported as mild and transient. In patients who have undergone radiotherapy, acupuncture is shown to increase salivation. However, in patients with Sjogren's syndrome, the effects of ES devices seem to be elusive. Moreover, due to the instability of the findings in relation to longevity of clinical effect, patient satisfaction, quality of life, and clinical effectiveness of such treatments, the results remain vague.
口干症是一种口腔干燥的主观感受。它通常与唾液腺功能减退有关。唾液成分的改变和分泌量的减少都可能是口干的客观表现。尽管目前尚无治愈导致口干症的疾病的方法,但有几种治疗选择为患有口干症的患者带来了希望。对于一些残留唾液腺功能且禁忌药物治疗的个体,识别刺激唾液分泌的新的替代有效方法将使其受益最大。本研究的目的是概述与口干症治疗方式相关的最新和最相关数据。本综述通过使用相关医学术语及其组合在国立医学图书馆数据库中进行检索而编写。共有33项研究符合纳入标准。数据由一位作者提取并由另一位作者核实。
许多患者显示出积极的治疗结果,并且电刺激(ES)和针灸的不良反应均被报告为轻微且短暂。在接受放疗的患者中,针灸可增加唾液分泌。然而,在干燥综合征患者中,ES设备的效果似乎难以捉摸。此外,由于这些治疗在临床效果持续时间、患者满意度、生活质量和临床有效性方面的研究结果不稳定,结果仍然不明确。