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强效钙离子动员剂环ADP-碳环核糖的5''-支链衍生物的合成：首批在N1-核糖部分修饰的拮抗剂。

Synthesis of 5''-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca2+-mobilizing agent: The first antagonists modified at the N1-ribose moiety.

作者信息

Sakaguchi Natsumi, Kudoh Takashi, Tsuzuki Takayoshi, Murayama Takashi, Sakurai Takashi, Matsuda Akira, Arisawa Mitsuhiro, Shuto Satoshi

机构信息

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.

出版信息

Bioorg Med Chem Lett. 2008 Jul 1;18(13):3814-8. doi: 10.1016/j.bmcl.2008.04.083. Epub 2008 May 20.

DOI:10.1016/j.bmcl.2008.04.083
PMID:18534848
Abstract

The 5''-branched cyclic ADP-carbocyclic-ribose derivatives were designed and synthesized. These target compounds were identified as the first antagonists of cADPR without a substituent at the adenine 8-position, and were shown to be stable due to the N1-carbocyclic-ribosyl structure.

摘要

设计并合成了5''-支链环ADP-碳环核糖衍生物。这些目标化合物被鉴定为腺嘌呤8位无取代基的cADPR的首批拮抗剂，并且由于N1-碳环核糖基结构而显示出稳定性。

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