使用4T高分辨率磁共振成像研究载脂蛋白E4在正常衰老和阿尔茨海默病中对海马CA3区和齿状回的选择性作用
Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T.
作者信息
Mueller S G, Schuff N, Raptentsetsang S, Elman J, Weiner M W
机构信息
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
出版信息
Neuroimage. 2008 Aug 1;42(1):42-8. doi: 10.1016/j.neuroimage.2008.04.174. Epub 2008 Apr 22.
BACKGROUND
Details of the internal hippocampal structure visible at 4 T allow for in vivo volumetry of subfields. The aims of this study were: 1. To determine if Apo e4 has subfield specific effects in controls. 2. To study the influence of Apo e4 on hippocampal subfields in AD.
METHODS
81 subjects (66 controls, mean age 60.8+/-13.6, range: 28-85 years), and 15 AD (mean age 67.5+/-9.3) were studied. Entorhinal cortex, subiculum, CA1, CA1-CA2 transition zone, CA3-4 and dentate gyrus (CA3&DG) and total hippocampal volume were determined using a manual marking strategy.
RESULTS
Significant effects for Apo e4 on the CA3&DG were found in the total control population (p=0.042) and in older controls (61-85 years) (p=0.036) but not in younger (28-60 years) controls. Significant effects for Apo e4 (p=0.0035) on CA3&DG were also found in a subgroup of older subjects and AD subjects. AD with Apo e4 had smaller CA3&DG than AD without Apo e4 (p=0.027).
CONCLUSIONS
These findings suggest that Apo e4 exerts a regionally selective effect on CA3&DG in normal aging and AD.
背景
4T磁共振成像可见的海马内部结构细节有助于进行亚区的活体体积测量。本研究的目的是：1. 确定载脂蛋白E4（Apo e4）在对照组中是否具有亚区特异性影响。2. 研究Apo e4对阿尔茨海默病（AD）海马亚区的影响。
方法
对81名受试者（66名对照组，平均年龄60.8±13.6岁，范围：28 - 85岁）和15名AD患者（平均年龄67.5±9.3岁）进行研究。采用手动标记策略确定内嗅皮质、下托、CA1、CA1 - CA2过渡区、CA3 - 4和齿状回（CA3&DG）以及海马总体积。
结果
在整个对照组人群（p = 0.042）和老年对照组（61 - 85岁）（p = 0.036）中发现Apo e4对CA3&DG有显著影响，但在年轻对照组（28 - 60岁）中未发现。在老年受试者和AD患者亚组中也发现Apo e4对CA3&DG有显著影响（p = 0.0035）。携带Apo e4的AD患者的CA3&DG比不携带Apo e4的AD患者小（p = 0.027）。
结论
这些发现表明，Apo e4在正常衰老和AD过程中对CA3&DG发挥区域选择性作用。
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