Dickey W, McAleer J J, Callender M E
Royal Victoria Hospital, Belfast.
Ulster Med J. 1991 Apr;60(1):49-52.
It has been suggested that the nicotinic acid provocation test is useful in the diagnosis of Gilbert's syndrome. We compared the response to intravenous nicotinic acid of patients with Gilbert's syndrome and with chronic liver disease. There was no significant difference in the mean rise in unconjugated serum bilirubin between the two groups. A sensitivity of 70% and specificity of 60% were obtained. All of 5 patients with chronic liver disease and a raised fasting unconjugated serum bilirubin had positive tests. We suggest that the nicotinic acid test is positive in unconjugated hyperbilirubinaemia regardless of cause. It is of no value in differentiating Gilbert's syndrome from liver disease.
有人提出烟酸激发试验对吉尔伯特综合征的诊断有用。我们比较了吉尔伯特综合征患者和慢性肝病患者对静脉注射烟酸的反应。两组间血清非结合胆红素的平均升高无显著差异。敏感性为70%，特异性为60%。所有5例慢性肝病且空腹血清非结合胆红素升高的患者试验均为阳性。我们认为，无论病因如何，烟酸试验在非结合性高胆红素血症中均为阳性。它在区分吉尔伯特综合征和肝病方面没有价值。
