Sun Shao-Cong
Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA.
Nat Rev Immunol. 2008 Jul;8(7):501-11. doi: 10.1038/nri2337.
Ubiquitylation is a fundamental mechanism of signal transduction that regulates immune responses and many other biological processes. Similar to phosphorylation, ubiquitylation is a reversible process that is counter-regulated by ubiquitylating enzymes and deubiquitylating enzymes (DUBs). Despite the identification of a large number of DUBs, our knowledge of the function and activities of this family of enzymes is just starting to accumulate. As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses.
泛素化是一种信号转导的基本机制，可调节免疫反应和许多其他生物学过程。与磷酸化类似，泛素化是一个可逆过程，由泛素化酶和去泛素化酶（DUBs）进行反向调节。尽管已经鉴定出大量的DUBs，但我们对该酶家族的功能和活性的了解才刚刚开始积累。正如本综述中所描述的，最近对几种DUBs的研究，特别是CYLD和A20，表明去泛素化在先天免疫和适应性免疫反应的调节中都起着重要作用。
