Dellweg D, Siemon K, Mahler F, Appelhans P, Klauke M, Köhler D
Krankenhaus Kloster Grafschaft, Schmallenberg.
Pneumologie. 2008 Jun;62(6):372-7. doi: 10.1055/s-2008-1038181.
The link between haemoglobin and physical performance was established a long time ago and is the underlying principle of blood doping. Blood loss on the other hand decreases physical capacity. The aim of this study is to evaluate physical performance loss and underlying mechanisms following voluntary blood donation.
Eleven voluntary subjects (four female) completed a symptom-limiting cardio-pulmonary exercise test before and after blood donation (500 mL blood).
The haemoglobin value decreased by 1.2 mg/dL (9%, p < 0.001), maximal oxygen uptake by 9% (p = 0.006), maximal work rate by 13% (p = 0.001) and duration of exercise fell from 663 down to 607 seconds (p = 0.005). Anaerobic transition occurred at 81.2% and 71.5% of maximal oxygen uptake before and after blood donation, respectively (p = 0.001). Subjects who practise recreational endurance sports appear to be more effected by endurance loss. The haemoglobin value was the only significant predictor of maximal oxygen uptake in regression analysis (p < 0.001).
Maximal physical performance is impaired after blood donation. Haemoglobin decline accounts for the decreased oxygen uptake. As a consequence thereof the anaerobic transition occurs earlier. Subjects not engaged in regular sports activity did not experience a decline in their capacity. Inclusion of the haemoglobin value into equations predicting maximal oxygen uptake could improve prediction precision.
血红蛋白与身体机能之间的联系早在很久以前就已确立，并且是血液兴奋剂的基本原理。另一方面，失血会降低身体机能。本研究的目的是评估自愿献血后身体机能的损失及其潜在机制。
11名自愿受试者（4名女性）在献血（500毫升血液）前后完成了症状限制性心肺运动试验。
血红蛋白值下降了1.2毫克/分升（9%，p<0.001），最大摄氧量下降了9%（p=0.006），最大工作率下降了13%（p=0.001），运动持续时间从663秒降至607秒（p=0.005）。献血前后无氧转换分别出现在最大摄氧量的81.2%和71.5%时（p=0.001）。进行休闲耐力运动的受试者似乎受耐力损失的影响更大。在回归分析中，血红蛋白值是最大摄氧量的唯一显著预测指标（p<0.001）。
献血后最大身体机能受损。血红蛋白下降导致摄氧量降低。因此，无氧转换会更早发生。未经常参加体育活动的受试者其身体机能并未下降。将血红蛋白值纳入预测最大摄氧量的公式中可提高预测精度。
