Chahine Mohamed, Chatelier Aurélien, Babich Olga, Krupp Johannes J
Le Centre de recherches Université Laval Robert-Griffard, Quebec City, Guebec, Canada.
CNS Neurol Disord Drug Targets. 2008 Apr;7(2):144-58. doi: 10.2174/187152708784083830.
Voltage-gated sodium channels play an essential biophysical role in many excitable cells such as neurons. They transmit electrical signals through action potential (AP) generation and propagation in the peripheral (PNS) and central nervous systems (CNS). Each sodium channel is formed by one alpha-subunit and one or more beta-subunits. There is growing evidence indicating that mutations, changes in expression, or inappropriate modulation of these channels can lead to electrical instability of the cell membrane and inappropriate spontaneous activity observed during pathological states. This review describes the biochemical, biophysical and pharmacological properties of neuronal voltage-gated sodium channels (VGSC) and their implication in several neurological disorders.
电压门控钠通道在许多可兴奋细胞（如神经元）中发挥着重要的生物物理作用。它们通过在周围神经系统（PNS）和中枢神经系统（CNS）中产生和传播动作电位（AP）来传递电信号。每个钠通道由一个α亚基和一个或多个β亚基组成。越来越多的证据表明，这些通道的突变、表达变化或不适当的调节可导致细胞膜电不稳定以及在病理状态下观察到的不适当的自发活动。本综述描述了神经元电压门控钠通道（VGSC）的生化、生物物理和药理学特性及其在几种神经系统疾病中的意义。
