Towers Craig V, Carr Margaret H
Division of Maternal-Fetal Medicine, Long Beach Memorial Women's Hospital, Long Beach, CA, USA.
Am J Obstet Gynecol. 2008 Jun;198(6):686.e1-5; discussion 686.e5. doi: 10.1016/j.ajog.2008.03.024.
The purpose of this study was to determine if antenatal fetal surveillance should be considered in pregnancies complicated by fetal gastroschisis, and if so, what gestational age should testing begin.
During an 18-year period, all pregnancies delivered of a newborn that had gastroschisis were identified. Numerous data parameters were collected, including gestational age at delivery, birthweight, indication for delivery, antenatal testing results if performed, and neonatal outcome. Fetal compromise was defined as stillbirth or moderate to severe arterial cord blood gas acidosis at the time of delivery (pH < 7.10).
During the study period, 84 pregnancies complicated by fetal gastroschisis were delivered from 117,564 gestations. Antenatal testing was performed in 58 cases (69%). Of the 26 (31%) without antenatal testing, 17 had an antenatal diagnosis of gastroschisis and in 9, the diagnosis was made on the day of delivery. In the 17 with an antenatal diagnosis, there were 2 stillbirths (29(4/7) and 31(3/7) weeks' gestation) and 1 was delivered with a moderate to severe arterial cord blood gas acidosis at 29(5/7) weeks' gestation. An additional case of moderate to severe arterial cord blood gas acidosis occurred in the 9 cases where the diagnosis was made on the day of delivery. Of the 58 pregnancies with antenatal surveillance, there were no stillbirths and no cases with a moderate to severe arterial cord blood gas acidosis. Of these 58 cases, 22 (38%) were delivered based on an abnormal testing result. Of the 84 total cases, 32 (38%) had birthweights < 10th percentile, and of these, 16 (19%) had birthweights < 3rd percentile.
Based on these data, antenatal fetal surveillance may be warranted in pregnancies complicated by fetal gastroschisis beginning at a gestational age of 28 to 29 weeks. Fetal testing between the thresholds of viability up to 28 weeks' gestation would be controversial.
本研究的目的是确定对于合并胎儿腹裂的妊娠是否应考虑进行产前胎儿监测,如果需要,监测应从什么孕周开始。
在18年期间,识别出所有分娩出患有腹裂新生儿的妊娠。收集了许多数据参数,包括分娩时的孕周、出生体重、分娩指征、若进行了产前检查的检查结果以及新生儿结局。胎儿窘迫定义为分娩时死产或中度至重度动脉血血气酸中毒(pH < 7.10)。
在研究期间,117,564次妊娠中有84次合并胎儿腹裂。58例(69%)进行了产前检查。在26例(31%)未进行产前检查的病例中,17例产前诊断为腹裂,9例在分娩当天确诊。在17例产前诊断的病例中,有2例死产(孕周分别为29(4/7)周和31(3/7)周),1例在29(5/7)周分娩时伴有中度至重度动脉血血气酸中毒。在分娩当天确诊的9例中,又有1例发生中度至重度动脉血血气酸中毒。在58例进行产前监测的妊娠中,没有死产病例,也没有中度至重度动脉血血气酸中毒病例。在这58例中,22例(38%)因检查结果异常而分娩。在84例总病例中,32例(38%)出生体重低于第10百分位数,其中16例(19%)出生体重低于第3百分位数。
基于这些数据,对于合并胎儿腹裂的妊娠,从孕28至29周开始进行产前胎儿监测可能是必要的。在孕28周之前的可存活阈值之间进行胎儿检查存在争议。