Lower Elyse E, Weiss Kenneth L
Interstitial Lung Disease and Sarcoidosis Center, University of Cincinnati Medical Center, 3235 Eden Avenue, Cincinnati, OH 45267, USA.
Clin Chest Med. 2008 Sep;29(3):475-92, ix. doi: 10.1016/j.ccm.2008.03.016.
Although neurosarcoidosis seems to occur in only 5% to 10% of patients who have sarcoidosis, it may lead to significant complications. The diagnosis of neurosarcoidosis usually relies on indirect information from imaging and spinal fluid examination. Although MR imaging remains the most sensitive technique for detecting neurologic disease, other tests, including positron emission tomography scanning and cerebral spinal fluid examination, can provide important information. The role of immunosuppressive agents such as methotrexate, cyclophosphamide, and azathioprine has been expanded, and these agents should be considered for the treatment of some manifestations of neurosarcoidosis. Reports of the antitumor necrosis factor agent infliximab suggest that this drug can be helpful for patients who have neurosarcoidosis.
尽管神经结节病似乎仅发生在5%至10%的结节病患者中，但它可能会导致严重的并发症。神经结节病的诊断通常依赖于影像学和脑脊液检查的间接信息。尽管磁共振成像仍是检测神经系统疾病最敏感的技术，但其他检查，包括正电子发射断层扫描和脑脊液检查，也能提供重要信息。甲氨蝶呤、环磷酰胺和硫唑嘌呤等免疫抑制剂的作用已得到扩展，对于神经结节病的某些表现，应考虑使用这些药物进行治疗。抗肿瘤坏死因子药物英夫利昔单抗的报告表明，这种药物对患有神经结节病的患者可能有帮助。
