Su Pen-Hua, Wang Shu-Li, Chen Jia-Yuh, Chen Suh-Jen, Ke Jui-Chen
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
J Pediatr Endocrinol Metab. 2008 Mar;21(3):213-20. doi: 10.1515/jpem.2008.21.3.213.
Premature thelarche in later childhood may progress to central precocious puberty (CPP), which does not spontaneously resolve. Thelarche variant (TV) is a slowly progressive variant of precocious puberty.
To determine and compare levels of insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3) and anthropomorphic measures in girls with TV and CPP.
Prepubertal controls and girls with TV and CPP.
Chronological and bone age, weight, height, BMI, height velocity (HV), and serum IGF-I, IGFBP-3, leptin, follicle-stimulating hormone (FSH) and lutenizing hormone (LH) levels were assessed.
Serum IGF-I levels, HV and IGF-I/ IGFBP-3 ratio were significantly higher in girls with CPP compared to both controls and girls with TV. IGFBP-3 values for bone age (IGFBP-3BA) were significantly higher in the TV group compared to both controls and girls with CPP. FSH and LH concentrations were significantly higher in the CPP group compared to TV.
HV, IGF-I, LH and FSH levels and IGF-I/IGFBP-3 ratio are elevated in girls with CPP compared to those with TV.
儿童后期的乳房过早发育可能会进展为中枢性性早熟（CPP），且不会自行消退。乳房过早发育变异型（TV）是性早熟的一种缓慢进展变异型。
确定并比较TV和CPP女童的胰岛素样生长因子-I（IGF-I）、IGF结合蛋白-3（IGFBP-3）水平及人体测量指标。
青春期前对照儿童以及患有TV和CPP的女童。
评估实足年龄和骨龄、体重、身高、体重指数（BMI）、身高增长速度（HV）以及血清IGF-I、IGFBP-3、瘦素、促卵泡生成素（FSH）和促黄体生成素（LH）水平。
与对照组和TV女童相比，CPP女童的血清IGF-I水平、HV以及IGF-I/IGFBP-3比值显著更高。与对照组和CPP女童相比，TV组的骨龄IGFBP-3值（IGFBP-3BA）显著更高。与TV女童相比，CPP组的FSH和LH浓度显著更高。
与TV女童相比，CPP女童的HV、IGF-I、LH和FSH水平以及IGF-I/IGFBP-3比值升高。
