Adams L G, Polzin D J, Osborne C A, O'Brien T D
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
Am J Vet Res. 1991 May;52(5):718-22.
The influence of induced chronic renal failure on 24-hour urinary excretion and fractional excretion of sodium and potassium was studied in cats. Induction of chronic renal failure significantly increased fractional excretion of potassium (P less than 0.0001) and sodium (P less than 0.05); however, 24-hour urinary excretion of sodium and potassium decreased slightly following induction of chronic renal failure. Fractional excretion and 24-hour urinary excretion of sodium and potassium were compared by linear regression in clinically normal cats, cats with chronic renal failure, and clinically normal and affected cats combined. In clinically normal cats, linear regression revealed only moderate correlation between fractional excretion and 24-hour urinary excretion for sodium and potassium. Linear regression of these same relationships in cats with chronic renal failure, and in clinically normal cats and cats with chronic renal failure combined, indicated low correlation. Fractional excretions of sodium and potassium were not reliable indicators of 24-hour urinary excretion of these electrolytes in cats with chronic renal failure or unknown glomerular filtration rate. Fractional excretion of potassium and sodium correlated only moderately with 24-hour urinary excretion in clinically normal cats.
在猫身上研究了诱导性慢性肾衰竭对24小时尿钠和钾排泄量以及钠和钾排泄分数的影响。诱导慢性肾衰竭显著增加了钾的排泄分数（P＜0.0001）和钠的排泄分数（P＜0.05）；然而，慢性肾衰竭诱导后，24小时尿钠和钾排泄量略有下降。对临床正常的猫、患有慢性肾衰竭的猫以及临床正常和患病猫合并组的钠和钾排泄分数及24小时尿排泄量进行线性回归比较。在临床正常的猫中，线性回归显示钠和钾的排泄分数与24小时尿排泄量之间仅存在中度相关性。对患有慢性肾衰竭的猫以及临床正常和患病猫合并组中这些相同关系进行线性回归，结果显示相关性较低。在患有慢性肾衰竭或肾小球滤过率未知的猫中，钠和钾的排泄分数并非这些电解质24小时尿排泄量的可靠指标。在临床正常的猫中，钾和钠的排泄分数与24小时尿排泄量仅存在中度相关性。
