血管内动脉瘤治疗的血流动力学：一种用于估计多个弹簧圈植入影响的计算建模方法。
The haemodynamics of endovascular aneurysm treatment: a computational modelling approach for estimating the influence of multiple coil deployment.
作者信息
Kakalis Nikolaos M P, Mitsos Aristotelis P, Byrne James V, Ventikos Yiannis
机构信息
Department of Engineering Science and the Institute of Biomedical Engineering, University of Oxford, Oxford OX1 3PJ, UK.
出版信息
IEEE Trans Med Imaging. 2008 Jun;27(6):814-24. doi: 10.1109/TMI.2008.915549.
This paper proposes a novel computational methodology for modelling the haemodynamic effects of endovascular coil embolization for cerebral aneurysms. We employ high-resolution 3-D angiographic data to reconstruct the intracranial geometry and we model the coiled part of the aneurysm as a porous medium, with porosity decreasing as coils are inserted. The actual dimensions of the coils employed are used to determine the characteristics of the porous medium. Simulation results for saccular aneurysms from the anterior communicating and middle cerebral arteries show that insertion of coils rapidly changes intraaneurysmal blood flow and causes reduction in mural pressure and blood velocity up to stagnation, providing favorable conditions for thrombus formation and obliteration of the aneurysm.
本文提出了一种新颖的计算方法，用于模拟脑动脉瘤血管内弹簧圈栓塞的血流动力学效应。我们利用高分辨率三维血管造影数据重建颅内几何结构，并将动脉瘤的盘绕部分建模为多孔介质，随着弹簧圈的插入，孔隙率会降低。所使用弹簧圈的实际尺寸用于确定多孔介质的特性。来自前交通动脉和大脑中动脉的囊状动脉瘤的模拟结果表明，弹簧圈的插入会迅速改变动脉瘤内的血流，并导致壁面压力和血流速度降低直至停滞，为血栓形成和动脉瘤闭塞提供了有利条件。
Zotero 插件