Dahse R, Kosmehl H
HELIOS Clinics Erfurt, Institute of Pathology, Nordhauser Street 74, Erfurt 99089, Germany.
Br J Cancer. 2008 Jul 8;99(1):90-2. doi: 10.1038/sj.bjc.6604430. Epub 2008 Jun 10.
Activating mutations within the epidermal growth factor receptor (EGFR) identify lung adenocarcinoma patients with improved clinical responses to tyrosine kinase inhibitors gefitinib and erlotinib. By screening salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland.
表皮生长因子受体(EGFR)内的激活突变可识别出对酪氨酸激酶抑制剂吉非替尼和厄洛替尼临床反应改善的肺腺癌患者。通过对唾液腺癌进行筛查,在腮腺的1例腺泡细胞癌和1例黏液表皮样癌中发现了2个具有药物敏感性的EGFR外显子19 delE746 - A750突变。