Tung Shih-Huang, Lee Hee-Young, Raghavan Srinivasa R
Department of Chemical & Biomolecular Engineering University of Maryland, College Park, Maryland 20742-2111, USA.
J Am Chem Soc. 2008 Jul 9;130(27):8813-7. doi: 10.1021/ja801895n. Epub 2008 Jun 11.
Reverse vesicles are spherical containers in organic liquids (oils) consisting of an oily core surrounded by a reverse bilayer. They are the organic counterparts to vesicles in aqueous solution and could potentially find analogous uses in encapsulation and controlled release. However, few examples of robust reverse vesicles have been reported, and general guidelines for their formation do not exist. We present a new route for forming stable unilamellar reverse vesicles in nonpolar organic liquids, such as cyclohexane and n-hexane. The recipe involves mixing short- and long-chain lipids (lecithins) with a trace of a salt such as sodium chloride. The ratio of short- to long-chain lecithin controls the type and size of self-assembled structure. As this ratio is increased, a spontaneous transition from reverse micelles to reverse vesicles occurs. Small-angle neutron scattering (SANS) and transmission electron microscopy (TEM) confirm the presence of unilamellar vesicles in the corresponding solutions. Average vesicle diameters can be tuned from 60 to 250 nm depending on the sample composition.
反相囊泡是有机液体（油）中的球形容器，由油性核心和包围它的反相双层组成。它们是水溶液中囊泡的有机对应物，在包封和控释方面可能有类似的用途。然而，很少有关于坚固反相囊泡的报道，也不存在形成它们的通用指导原则。我们提出了一种在非极性有机液体（如环己烷和正己烷）中形成稳定单层反相囊泡的新方法。该方法包括将短链和长链脂质（卵磷脂）与微量盐（如氯化钠）混合。短链与长链卵磷脂的比例控制着自组装结构的类型和大小。随着该比例的增加，会发生从反相胶束到反相囊泡的自发转变。小角中子散射（SANS）和透射电子显微镜（TEM）证实了相应溶液中存在单层囊泡。根据样品组成，平均囊泡直径可在60至250纳米之间调节。
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