Freeman Lyn, Cohen Lorenzo, Stewart Mary, White Rebecca, Link Judith, Palmer J Lynn, Welton Derek
Mind Matters Research, Anchorage, AK 99507, USA.
J Soc Integr Oncol. 2008 Spring;6(2):67-75.
In a phase I National Cancer Institute (NCI)-funded clinical trial, 34 breast cancer survivors, six weeks to one year post-treatment, were recruited to participate in a 6-class, 8-week long imagery stress reduction program entitled "Envision the Rhythms of Life." Patients practiced imagery during and between sessions. Outcomes for quality of life and cortisol rhythm were assessed pre- to post-intervention, in two subsets of survivors (intravenous [IV] chemotherapy, or no IV chemotherapy). Thirty survivors completed the 8-week program. Quality of life outcomes demonstrated statistically and clinically significant outcomes for the functional assessment of cancer therapy-general (FACT-G) global index (p<.001), representing improvements in survivor quality of life related to physical, social/family, emotional, and function well-being. Survivors also improved significantly on the breast cancer (p<.001) and spiritual subscales (p = .008.) Brief symptom inventory (BSI) assessment reported significant improvement for the global index (p<.001) which included the categories of depression, somatization and anxiety. At eight weeks, cortisol rhythm, a biochemical indicator of stress and likelihood of cancer recurrence, produced a trend toward improvement for the fifth time point of the day (p = .18). Likert-based stress scales showed highly significant reductions in stress (p<.0001) with subjects practicing imagery the most producing the best scores. Outcomes suggest the imagery program may significantly improve survivor quality of life and reduce stress.
在一项由美国国立癌症研究所（NCI）资助的I期临床试验中，招募了34名乳腺癌幸存者，她们在治疗后6周至1年，参加了一个名为“想象生命的节奏”的为期8周、共6节课的意象减压项目。患者在课程期间及课间练习意象。在干预前后，对两个幸存者亚组（静脉注射[IV]化疗组或非静脉注射化疗组）的生活质量和皮质醇节律结果进行了评估。30名幸存者完成了为期8周的项目。生活质量结果显示，癌症治疗功能评估通用量表（FACT-G）全球指数具有统计学和临床意义上的显著结果（p<.001），这代表了幸存者在身体、社会/家庭、情感和功能幸福感方面生活质量的改善。幸存者在乳腺癌亚量表（p<.001）和精神亚量表（p = .008）上也有显著改善。简明症状量表（BSI）评估报告显示，包括抑郁、躯体化和焦虑类别的全球指数有显著改善（p<.001）。在第8周时，皮质醇节律作为压力和癌症复发可能性的生化指标，在一天中的第五个时间点呈现出改善趋势（p = .18）。基于李克特量表的压力量表显示，压力有极显著降低（p<.0001），练习意象最多的受试者得分最佳。结果表明，意象项目可能显著改善幸存者的生活质量并减轻压力。
