[细胞色素P450 1A2的研究进展]
[Advance in cytochrome P450 1A2].
作者信息
Xiao Peng, Zhou Hong-hao
机构信息
Institute of Clinical Pharmacology, Central South University, Changsha, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 May;33(5):456-60.
PMID:18544853
Abstract
CYP1A2 is an important cytochrome P450 enzymes, which is involved in metabolism of many clinical drugs and activation of some precarcinogens. CYP1A2 activity can be influenced by various factors including genetic polymorphism, drugs, food and so on, in which the CYP1A2 genetic polymorphism is the basis of difference on the activity and induction of CYP1A2. Therefore,the genotyping of CYP1A2 plays an important part in individualization of therapy.
摘要
CYP1A2是一种重要的细胞色素P450酶，参与多种临床药物的代谢以及一些前致癌物的激活。CYP1A2的活性会受到多种因素影响，包括基因多态性、药物、食物等，其中CYP1A2基因多态性是CYP1A2活性及诱导差异的基础。因此，CYP1A2基因分型在个体化治疗中发挥着重要作用。
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