瘦素受体基因Lys656Asn多态性对两种低热量饮食后瘦素反应的影响：一项随机临床试验

Influence of Lys656Asn polymorphism of leptin receptor gene on leptin response secondary to two hypocaloric diets: a randomized clinical trial.

作者信息

de Luis D A, Aller R, Izaola O, Sagrado M Gonzalez, Conde R

机构信息

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, RD056/0013 Valladolid, Spain.

出版信息

Ann Nutr Metab. 2008;52(3):209-14. doi: 10.1159/000138125. Epub 2008 Jun 11.

DOI:10.1159/000138125

PMID:18544975

Abstract

BACKGROUND

Human obesity is characterized by high levels of leptin, and it has been suggested that obese patients may be leptin-resistant.

OBJECTIVE

The aim of our study was to investigate the influence of Lys656Asn polymorphism in the LEPR gene on leptin response secondary to a low fat versus a low carbohydrate diet in obese patients.

DESIGN

A population of 78 obesity patients was enrolled. Before and after 2 months of two diets, a nutritional evaluation was performed.

RESULTS

52 patients had genotype Lys656/Lys656 (wild group) and 26 patients Lys656/Asn656 or Asn656/Asn656 (mutant group). In the low fat and wild groups, BMI, weight, fat mass, glucose, total cholesterol, triglyceride, insulin, and blood pressure decreased. In mutant type (MT), BMI, weight and fat mass decreased. In wild type (WT) with low carbohydrate diet, BMI, weight, fat mass, waist circumference, waist-to-hip ratio, total cholesterol, and blood pressures decreased. In MT, BMI, weight and fat mass decreased. Only leptin concentrations have a significant decrease in WT with both diets (diet I: 30.3%; p < 0.05) and (diet II: 15.5%; p < 0.05).

CONCLUSION

In WT patients, the changes in serum leptin concentration due to 2 months' intervention with low fat are higher than with a low carbohydrate diet.

摘要

背景

人类肥胖的特征是瘦素水平升高，有人提出肥胖患者可能存在瘦素抵抗。

目的

我们研究的目的是调查肥胖患者中LEPR基因Lys656Asn多态性对低脂饮食与低碳水化合物饮食继发的瘦素反应的影响。

设计

招募了78名肥胖患者。在两种饮食干预2个月前后，进行了营养评估。

结果

52例患者为Lys656/Lys656基因型（野生组），26例患者为Lys656/Asn656或Asn656/Asn656基因型（突变组）。在低脂饮食组和野生组中，体重指数（BMI）、体重、脂肪量、血糖、总胆固醇、甘油三酯、胰岛素和血压均下降。在突变型（MT）中，BMI、体重和脂肪量下降。在低碳水化合物饮食的野生型（WT）中，BMI、体重、脂肪量、腰围、腰臀比、总胆固醇和血压均下降。在MT中，BMI、体重和脂肪量下降。仅在两种饮食的WT中瘦素浓度显著下降（饮食I：30.3%；p<0.05）和（饮食II：15.5%；p<0.05）。