使用光纤耦合偏振分辨拉曼光谱系统进行早期龋齿检测。
Early dental caries detection using a fibre-optic coupled polarization-resolved Raman spectroscopic system.
作者信息
Ko Alex C-T, Hewko Mark, Sowa Michael G, Dong Cecilia C S, Cleghorn Blaine, Choo-Smith Lin-P'ing
机构信息
Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Manitoba, Canada R3B 1Y6.
出版信息
Opt Express. 2008 Apr 28;16(9):6274-84. doi: 10.1364/oe.16.006274.
Abstract
A new fibre-optic coupled polarization-resolved Raman spectroscopic system was developed for simultaneous collection of orthogonally polarized Raman spectra in a single measurement. An application of detecting incipient dental caries based on changes observed in Raman polarization anisotropy was also demonstrated using the developed fibre-optic Raman spectroscopic system. The predicted reduction of polarization anisotropy in the Raman spectra of caries lesions was observed and the results were consistent with those reported previously with Raman microspectroscopy. The capability of simultaneous collection of parallel- and cross-polarized Raman spectra of tooth enamel in a single measurement and the improved laser excitation delivery through fibre-optics demonstrated in this new design illustrates its future clinical potential.
摘要
开发了一种新型光纤耦合偏振分辨拉曼光谱系统，用于在单次测量中同时采集正交偏振拉曼光谱。还利用所开发的光纤拉曼光谱系统展示了基于拉曼偏振各向异性变化检测早期龋齿的应用。观察到龋齿病变拉曼光谱中偏振各向异性的预测降低，结果与先前用拉曼显微光谱报道的结果一致。这种新设计中展示的在单次测量中同时采集牙釉质平行和交叉偏振拉曼光谱的能力以及通过光纤改善的激光激发传输，说明了其未来的临床潜力。
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