Ganio E, Marino F, Giani I, Luc A Realis, Clerico G, Novelli E, Trompetto M
Colorectal Eporediensis Centre, Clinica S. Rita, Vercelli, Italy.
Tech Coloproctol. 2008 Jun;12(2):99-102. doi: 10.1007/s10151-008-0406-x. Epub 2008 Jun 10.
Passive fecal incontinence is a disabling condition caused by internal anal sphincter dysfunction. The aim of the study was to assess prospectively the effects of calcium hydroxylaptatite ceramic microspheres (Coaptite) as a bulking agents to treat patients with passive fecal incontinence.
Ten patients with passive fecal incontinence were recruited. All patients were assessed by clinical examination, anal ultrasonography and anal manometry. The severity of incontinence and quality of life were assessed using the Fecal Incontinence Scoring System (FISS) and Fecal Incontinence Quality of Life (FIQoL) questionnaire at baseline and at 3, 6 and 12 months after the Coaptite injection.
Eight patients (80%) had a marked improvement in continence, with a significant reduction in FISS from 85.6+/-9.4 to 28.0+/-29.0 (p=0.008) at 12 months. There was an improvement in global quality of life scores, which was significant in three subscales (lifestyle, coping/behaviour and embarrassment). Manometry showed a significant improvement from baseline in the mean resting anal canal pressure after the Coaptite injection (p=0.018).
Coaptite is a promising and safe bulking agent for the treatment of passive fecal incontinence
被动性大便失禁是一种由肛门内括约肌功能障碍引起的致残性病症。本研究的目的是前瞻性评估羟基磷灰石钙陶瓷微球（Coaptite）作为一种填充剂治疗被动性大便失禁患者的效果。
招募了10例被动性大便失禁患者。所有患者均通过临床检查、肛门超声检查和肛门测压进行评估。在基线时以及注射Coaptite后3个月、6个月和12个月，使用大便失禁评分系统（FISS）和大便失禁生活质量（FIQoL）问卷评估失禁的严重程度和生活质量。
8例患者（80%）的控便能力有显著改善，12个月时FISS从85.6±9.4显著降至28.0±29.0（p = 0.008）。总体生活质量评分有所改善，在三个子量表（生活方式、应对/行为和尴尬）中具有显著性。测压显示注射Coaptite后平均静息肛管压力较基线有显著改善（p = 0.018）。
Coaptite是一种有前景且安全的用于治疗被动性大便失禁的填充剂。
