Owczuk R, Wujtewicz M A, Sawicka W, Piankowski A, Polak-Krzeminska A, Morzuch E, Wujtewicz M
Department of Anaesthesiology and Intensive Therapy, Medical University of Gdansk, Gdansk, Poland.
Anaesthesia. 2008 Sep;63(9):924-31. doi: 10.1111/j.1365-2044.2008.05525.x. Epub 2008 Jun 10.
Laryngoscopy and tracheal intubation may provoke changes of cardiac repolarisation. The aim of this study was to assess the effect of intravenous lidocaine on the ECG changes induced by laryngoscopy and tracheal intubation. Forty-three female patients were randomly allocated to receive lidocaine (1.5 mg.kg(-1)) or placebo immediately after induction of anaesthesia and changes in the ECG and arterial blood pressure were recorded. Correction of QT interval was calculated using Bazett's formula (QTcb), Fridericia's correction (QTcf), and Framingham formula (QTcF). Transmural dispersion of repolarisation (TDR) was determined as Tpeak-Tend time. There were no changes in the QTc value in the lidocaine group. In the placebo group, significant increases in QTcb, QTcf and QTcF values were observed after intubation compared to either control measurements or to comparative measurements in the lidocaine group. There were no significant differences in TDR either between or within the groups. Lidocaine diminishes prolongation of QTc, induced by tracheal intubation but there is no effect of intubation on TDR.
喉镜检查和气管插管可能会引起心脏复极的变化。本研究的目的是评估静脉注射利多卡因对喉镜检查和气管插管所致心电图变化的影响。43例女性患者在麻醉诱导后立即被随机分配接受利多卡因（1.5mg·kg⁻¹）或安慰剂，并记录心电图和动脉血压的变化。使用巴泽特公式（QTcb）、弗里德里西亚校正公式（QTcf）和弗雷明汉公式（QTcF）计算QT间期校正值。复极跨壁离散度（TDR）被确定为T波峰值与T波终末间期。利多卡因组的QTc值没有变化。在安慰剂组中，与对照组测量值或利多卡因组的对比测量值相比，插管后观察到QTcb、QTcf和QTcF值显著增加。组间或组内的TDR均无显著差异。利多卡因可减少气管插管引起的QTc延长，但插管对TDR没有影响。
