托吡酯和阿立哌唑治疗后烟草消费量减少：一例报告。
Decrease in tobacco consumption after treatment with topiramate and aripiprazole: a case report.
作者信息
Arbaizar Beatriz, Gómez-Acebo Inés, Llorca Javier
机构信息
Unit of Mental Health, Hospital de Laredo, Laredo, Spain.
出版信息
J Med Case Rep. 2008 Jun 11;2:198. doi: 10.1186/1752-1947-2-198.
Abstract
INTRODUCTION
A large part of research into drug addiction focuses on mesolimbic dopamine circuitry; however, both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate and dopamine D2 receptors can play a role in maintaining the established addiction.
CASE PRESENTATION
We report the case of a 34-year-old man who compulsively smoked 80 to 100 cigarettes each day. After receiving treatment with topiramate and aripiprazole, his tobacco consumption was dramatically reduced.
CONCLUSION
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate blocking agents and a dopamine D2 receptor partial agonist may be novel instruments for nicotine abuse disorders.
摘要
引言
药物成瘾研究的很大一部分集中在中脑边缘多巴胺回路；然而，α-氨基-3-羟基-5-甲基-4-异恶唑丙酸和/或海人藻酸以及多巴胺D2受体在维持已形成的成瘾中都可能起作用。
病例报告
我们报告了一名34岁男性的病例，他每天强迫性地吸食80至100支香烟。在接受托吡酯和阿立哌唑治疗后，他的烟草消费量大幅减少。
结论
α-氨基-3-羟基-5-甲基-4-异恶唑丙酸和/或海人藻酸阻断剂以及多巴胺D2受体部分激动剂可能是治疗尼古丁滥用障碍的新型药物。
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