[两栖动物发育过程中甲状腺激素反应基因调控的潜在机制]
[Mechanisms underlying thyroid hormone response gene regulation during amphibian development].
作者信息
Havis Emmanuelle, Bilesimo Patrice, Demeneix Barbara A, Sachs Laurent M
机构信息
UMR5166 CNRS, USM-501 Muséum National d'Histoire Naturelle, Département Régulation Développement et Diversité Moléculaire, CP32, 7 rue Cuvier, 75231 Paris Cedex 05, France.
出版信息
J Soc Biol. 2008;202(2):73-81. doi: 10.1051/jbio:2008009. Epub 2008 Jun 13.
Amphibian metamorphosis is an excellent model to study the diverse effects of thyroid hormones (TH). TH modulate target gene expression via thyroid hormone receptors (TR). Generally, unliganded TR repress transcription, whereas liganded TR activate transcription. During metamorphosis, these dual effects of TR are evident. Moreover, we show that gene specific response to TH can underline the multiple effects of TH. Finally, studies of unliganded-thyroid hormone receptor function reveal a physiological role in eye development.
两栖动物变态是研究甲状腺激素（TH）多种作用的绝佳模型。甲状腺激素通过甲状腺激素受体（TR）调节靶基因表达。一般来说，未结合配体的TR抑制转录，而结合配体的TR激活转录。在变态过程中，TR的这两种作用很明显。此外，我们表明，基因对甲状腺激素的特异性反应可以突出甲状腺激素的多种作用。最后，对未结合配体的甲状腺激素受体功能的研究揭示了其在眼睛发育中的生理作用。
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