Sun Shilong, Wang Fan, Wei Jun, Cao Lian Yuan, Wu Gui Ying, Lu Lin, Kosten Therese A, Kosten Thomas R, Zhang Xiang Yang
Research Center for Neuroscience and MH Radiobiology Research Unit, Jilin University, Changchun, PR China.
Neurosci Lett. 2008 Jul 25;440(1):35-7. doi: 10.1016/j.neulet.2008.05.029. Epub 2008 May 15.
Schizophrenia has been observed to be associated with various abnormalities in cytokines and cytokine receptors. Three very recent reports showed the evidence that the IL3 gene, colony stimulating factor 2 receptor alpha (CSF2RA), beta (CSF2RB) and IL-3 receptor alpha (IL3RA), the IL-specific receptor subunits for CSF2 and IL3, respectively, are associated with schizophrenia. To examine the association of the IL3RA polymorphism (rs6603272) with schizophrenia in a Chinese population, 310 physically healthy patients with schizophrenia were compared with 330 age-, sex- matched normal controls. Statistically significant differences were observed in both allelic and genotypic frequencies of the rs6603272 polymorphism (Allele, chi2=6.24, d.f.=1, p=0.013, odds ratio (OR)=1.35, 95% CI 1.07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia.
已有研究观察到，精神分裂症与细胞因子及细胞因子受体的多种异常有关。最近的三项报告显示，有证据表明IL3基因、集落刺激因子2受体α（CSF2RA）、β（CSF2RB）以及IL-3受体α（IL3RA）（分别为CSF2和IL3的IL特异性受体亚基）与精神分裂症有关。为了研究中国人群中IL3RA基因多态性（rs6603272）与精神分裂症的关联，将310名身体健康的精神分裂症患者与330名年龄和性别匹配的正常对照进行了比较。在rs6603272多态性的等位基因频率和基因型频率上均观察到统计学显著差异（等位基因，χ2 = 6.24，自由度 = 1，p = 0.013，优势比（OR）= 1.35，95%可信区间1.07 - 1.71；基因型，χ2 = 6.85，自由度 = 2，p = 0.033）。我们的结果表明，IL3RA基因多态性对精神分裂症易感性有微小但显著的影响，提示IL3通路可能参与了精神分裂症的发病过程。
