Novozheeva T P, Saratikov A S, Grishanova A Iu, Gutkina N I, Akhmedzhanov R R, Khatsenko O G, Kozlovskaia N E
Biull Eksp Biol Med. 1991 Feb;111(2):163-5.
It has been found that the Soviet anticonvulsant drug Benzonal is an inducer of the liver cytochrome P-450 of the phenobarbital type. The drug causes formation of the cytochrome P-450 form which is immunologically identical to the phenobarbital inducible form of the hemoprotein with identical molecular mass determined with the SDS-gel electrophoresis method in PAAG. The microsomes, obtained from the rats treated with Benzonal display increased rates of metabolism of 7-pentoxiresorufin and 16 beta-hydroxylation of androstenedione which are specific substrates for the cytochrome P-450b.
已发现苏联的抗惊厥药物苯唑那是苯巴比妥类型的肝脏细胞色素P - 450诱导剂。该药物会导致细胞色素P - 450形式的形成，这种形式在免疫学上与血蛋白的苯巴比妥诱导形式相同，且通过聚丙烯酰胺凝胶（PAAG）中的SDS - 凝胶电泳法测定具有相同的分子量。从用苯唑那处理过的大鼠获得的微粒体显示出7 - 戊氧基试卤灵代谢速率增加以及雄烯二酮16β - 羟基化增加，而7 - 戊氧基试卤灵和雄烯二酮是细胞色素P - 450b的特异性底物。
