Gidoni Yariv, Holzer Hananel, Tulandi Togas, Tan Seang Lin
Department of Obstetrics and Gynecology, McGill University, 687 Pine Avenue West, Montreal, H3A 1A1, Quebec, Canada.
Reprod Biomed Online. 2008 Jun;16(6):792-800. doi: 10.1016/s1472-6483(10)60144-7.
In addition to cancers, many non-oncological conditions, including chromosomal abnormalities and autoimmune disorders, are currently treated with gonadotoxic agents that can lead to premature ovarian failure. Because of the young age of some of the women affected by these conditions, attempts to preserve fertility and ovarian function are recommended. To date, retrieval of immature oocytes followed by in-vitro maturation and vitrification has been found to be especially useful for women who cannot undergo ovarian stimulation, or when there is a contraindication.
除癌症外，许多非肿瘤性疾病，包括染色体异常和自身免疫性疾病，目前都使用可能导致卵巢早衰的性腺毒性药物进行治疗。由于受这些疾病影响的一些女性年龄较小，建议尝试保留生育能力和卵巢功能。迄今为止，对于无法进行卵巢刺激或存在禁忌证的女性，获取未成熟卵母细胞然后进行体外成熟和玻璃化冷冻已被证明特别有用。
