Musaev S N, Novikova A V, Shershevskaia A Ia, Klimanskaia E V, Aksenova I V
Biull Eksp Biol Med. 1991 Feb;111(2):203-6.
Histological, morphometric, and immunohistochemical studies of biopsy specimens from the mucosa of the body and antral portion of the stomach, the bulb and descending portion of the duodenum were performed in 27 children with systemic lupus erythematosis (SLE) and in 12 with chronic gastroduodenitis. The inflammatory infiltrate from SLE patients was found to contain higher levels of young and mature fibroblasts than that from patients with chronic gastroduodenitis, mature fibroblasts being prevalent. The inflammatory changes in the gastric and duodenal mucosa were ascertained to be associated with the progression of SLE. In exacerbation of SLE, the walls of vessels (arterioles) exhibited immune complexes classified mainly as IgG and, to a lesser degree, as IgM. In remission, the luminescence of the vessels decreased. The serum level of immunoglobins did not correlate with their regional production in the gastric and duodenal mucosa.
对27例系统性红斑狼疮（SLE）患儿和12例慢性胃十二指肠炎症患儿的胃体和胃窦部黏膜、十二指肠球部及降部活检标本进行了组织学、形态计量学和免疫组化研究。结果发现，SLE患者的炎性浸润中年轻和成纤维细胞水平高于慢性胃十二指肠炎症患者，以成熟成纤维细胞为主。胃和十二指肠黏膜的炎症变化被确定与SLE的进展有关。在SLE加重期，血管（小动脉）壁出现主要分类为IgG的免疫复合物，IgM较少。在缓解期，血管的荧光减弱。免疫球蛋白的血清水平与其在胃和十二指肠黏膜中的局部产生无关。
