Vitale V, Franzone P
Istituto Nazionale per la Ricerca sul Cancro, Genova.
Bone Marrow Transplant. 1991;7 Suppl 3:32-4.
TBI is currently used as a conditioning regimen in bone marrow transplantation (BMT) with various Radiation doses, fractionation scheduling and dose rate. In children, the most frequent neoplasms treated with TBI are leukemias and advanced Neuroblastoma (NB). In leukemias the radiation dose plays an important role, particularly in patients at high risk of relapse. In NB the inclusion of TBI in pretransplant therapy does not seem to produce any difference in survival. In pediatric patients TBI involved particular problems of technique dosimetry and toxicity.
目前，全脑照射（TBI）在骨髓移植（BMT）中被用作预处理方案，采用了各种不同的辐射剂量、分割方案和剂量率。在儿童中，接受TBI治疗的最常见肿瘤是白血病和晚期神经母细胞瘤（NB）。在白血病中，辐射剂量起着重要作用，尤其是在复发风险高的患者中。在NB中，移植前治疗中加入TBI似乎对生存率没有任何影响。在儿科患者中，TBI涉及技术剂量测定和毒性等特殊问题。
